Role of ferroptosis in Parkinson’s disease and intervention mechanism of acupuncture and moxibustion  

作　　者：Xiao-Qian Hao Shu-Ping Zhu Qing-Lian Li Da Gao Xiao-Ling Wang Qi-Zhang Wang Mei-Ling Zhu 

机构地区：[1]Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine,Guangzhou University of Chinese Medicine,Shenzhen 518100,China

出　　处：《Aging Communications》2023年第3期23-27,共5页衰老通讯

基　　金：This work was supported by,the Shenzhen Science and Technology Program(JCYJ20210324123614040);the Guangdong Basic and Applied Basic Research Foundation(Grant No.2022A151510450);the Medical Scientific Research Foundation of Guangdong Province(No.B2023087);the Sanming Project of Medicine in Shenzhen(Grant No.SZZYSM202106009);the Bao’an TCM Development Foundation(Grant No.2022KJCX-ZJZL-7);National Administration of Traditional Chinese Medicine(GZY-FJS-2022-59).

摘　　要：Parkinson’s disease(PD)is the second neurodegenerative disease in the world.The pathological characteristics of PD are degeneration,loss and death of dopaminergic neurons in the substantia nigra of the midbrain.At present,most scholars believe that the main pathogenesis of PD is α-synuclein aggregation,oxidative stress,mitochondrial dysfunction and neuroinflammatory reaction.More and more studies have demonstrated that ferroptosis plays an important role in the occurrence and development of PD.Ferroptosis is a new type of cell death that is significantly different from traditional apoptosis,scorching and necrosis.Its main feature is iron-dependent lipid peroxidation.Some studies have found that the efficacy of acupuncture and moxibustion in the treatment of PD may be related to the regulation of ferroptosis.Therefore,this study mainly discusses the occurrence and development mechanism of ferroptosis and its role in PD,and the possible mechanism of acupuncture and moxibustion in the treatment of PD dopaminergic neurons,so as to provide theoretical basis for acupuncture and moxibustion in the treatment of PD.

关 键 词：ferroptosis Parkinson’s disease ACUPUNCTURE MOXIBUSTION intervention mechanism 

分 类 号：R24[医药卫生—中医临床基础]