高效液相色谱法测定甲基丙烯酸-2-羟基乙酯和2,2-二甲氧基-2-苯基苯乙酮  

An HPLC-Based Method for Determination of 2-Hydroxyethyl Methacrylate and 2,2-Dimethoxy-2-Phenylacetophenone

作　　者：李阳 丁雪佳[3] 李俊付 李仕鹏 石刘辉 陈圣军 吴焱 李新东 LI Yang;DING Xue-jia;LI Jun-fu;LI Shi-peng;SHI Liu-hui;CHEN Sheng-jun;WU Yan;LI Xin-dong(Henan Tuoren Medical Instrument Group Co.,Ltd.,Xinxiang 453400,China;Henan Key Laboratory of Medical Polymer Materials Technology and Application,Xinxiang 453400,China;Beijing University of Chemical Technology,Beijing 100029,China)

机构地区：[1]河南驼人医疗器械集团有限公司,河南新乡453400 [2]河南省医用高分子材料技术与应用重点实验室,河南新乡453400 [3]北京化工大学,北京100029

出　　处：《塑料科技》2023年第8期87-91,共5页Plastics Science and Technology

摘　　要：文章建立快速测定甲基丙烯酸-2-羟基乙酯(HEMA)和2,2-二甲氧基-2-苯基苯乙酮(DMPA)的高效液相色谱分析方法。采用紫外/可见波长检测器,检测波长为220 nm;采用Waters XBridge C_(18)柱;流动相为甲醇-水梯度洗脱,流量为1.0 mL/min。结果表明:HEMA和DMPA在0.5~200.0μg/mL和0.5~20.0μg/mL范围内均保持良好线性关系,相关系数(r)均在0.999以上,回收率在90%~110%之间,变异系数(RSD)小于0.5%。本方法准确、灵敏、快速、重复性好,能够在10 min内同时快速检测HEMA和DMPA两种物质。A high performance liquid chromatographic(HPLC)method was developed for rapid determination of 2-hydroxyethyl methacrylate(HEMA)and 2,2-dimethoxy-2-phenylacetophenone(DMPA).The ultraviolet/visible wavelength detector was used,and detection wavelength was 220 nm.Waters XBridge C_(18) column was used.The mobile phase was methanol-water gradient elution,and flow rate was 1.0 mL/min.The results show that HEMA and DMPA maintain a good linear relationship in the range of 0.5~200.0μg/mL and 0.5~20.0μg/mL,the correlation coefficient(r)is above 0.999,the recovery rate is 90%~110%,and the coefficient of variation(RSD)is less than 0.5%.The method is accurate,sensitive,rapid and reproducible,and can simultaneously and rapidly detect HEMA and DMPA within 10 min.

关 键 词：高效液相色谱法 甲基丙烯酸-2-羟基乙酯 2 2-二甲氧基-2-苯基苯乙酮 

分 类 号：O657.7[理学—分析化学]