维持性血液透析患者平均血小板体积及β_(2)-微球蛋白对心脏瓣膜钙化的影响  

Eff ect of MPV andβ_(2)-microglobulin on cardiac valve calcifi cation in patients on maintenance hemodialysis

作　　者：姚转娥 王鹏波 付秦娟 王薇 宋琼 李欢 刘爱 张鹏 Yao Zhuan’e;Wang Pengbo;Fu Qinjuan;Wang Wei;Song Qiong;Li Huan;Liu Ai;Zhang Peng(Department of Nephrology,the Second People’s Hospital of Shanxi Province,Xi’an 710005,China)

机构地区：[1]陕西省第二人民医院肾病内科,西安710005 [2]空军军医大学西京医院肾病内科,西安710000

出　　处：《新医学》2023年第9期634-638,共5页Journal of New Medicine

基　　金：陕西省卫生健康科研基金(2022E013)。

摘　　要：目的探讨维持性血液透析患者平均血小板体积(MPV)和β_(2)-微球蛋白与心脏瓣膜钙化(CVC)的关系,为CVC的临床预测和诊断提供依据。方法选择行规律血液透析患者70例,根据有无CVC分为2组,无CVC组36例,有CVC组34例,比较2组患者性别、年龄、透析龄、血磷、血钙、甲状旁腺激素、25-羟维生素D3、白蛋白、前白蛋白、铁、不饱和铁、转铁蛋白、铁蛋白、总铁结合力、碱性磷酸酶、血脂、β_(2)-微球蛋白、MPV、中性粒细胞与淋巴细胞比值(NLR)的差异,并应用Logistic回归分析CVC发生的危险因素。结果与无CVC组比较,CVC组的年龄、透析龄、MPV、β_(2)-微球蛋白、NLR均明显升高,差异均有统计学意义(P均<0.05)。Logistic回归分析结果显示,年龄(OR=1.101,P=0.018)、MPV(OR=2.894,P=0.003)、β_(2)-微球蛋白(OR=1.064,P=0.038)是维持性血液透析患者发生CVC的独立危险因素。结论MPV及β_(2)-微球蛋白与维持性血液透析患者CVC发生、发展密切相关,是影响CVC的独立危险因素。Objective To investigate the relationship between mean platelet volume(MPV)andβ_(2)-microglobulin and cardiac valve calcifi cation(CVC)in maintenance hemodialysis patients,aiming to provide a basis for clinical prediction and diagnosis of CVC.Meth ods Seventy patients on regular hemodialysis were selected and divided into the non-CVC(n=36)and CVC groups(n=34)according to the presence or absence of CVC.Gender,age,dialysis age,blood phosphorus,blood calcium,parathyroid hormone,25 hydroxy-vitamin D3,albumin,prealbumin,iron,unsaturated iron,transferrin,ferritin total iron binding capacity,alkaline phosphatase,lipids,β_(2)-microglobulin,MPV and neutrophil-to-lymphocyte ratio(NLR)were statistically compared between two groups.The risk factors for the incidence of CVC were assessed by Logistic regression analysis.Results Compared with the non-CVC group,age,dialysis age,MPV,β_(2)-microglobulin and NLR were signifi cantly higher in the CVC group,and all diff erences were statistically signifi cant(all P<0.05).Logistic regression analysis showed that age(OR=1.101,P=0.018),MPV(OR=2.894,P=0.003),andβ_(2)-microglobulin(OR=1.064,P=0.038)were the independent risk factors for the incidence of CVC in maintenance hemodialysis patients.Conclusion MPV andβ_(2)-microglobu lin are closely associated with the occurrence and development of CVC in maintenance hemodialysis patients,which are independent risk factors aff ecting CVC.

关 键 词：平均血小板体积 β_(2)-微球蛋白 血液透析 瓣膜钙化 

分 类 号：R692.5[医药卫生—泌尿科学]