改善复方板蓝根颗粒溶化性研究  

Study on Improving the Solubility of Compound Banlangen Granules

作　　者：李璐晏 余祥安 曾凡玉 Li Luyan;Yu Xiang’an;Zeng Fanyu(Taiji Group Chongqing No.2 Chinese Medicine Factory Co.,Ltd.,Chongqing 402260;Chongqing Taiji Industry(Group)Co.,Ltd.,Chongqing 408000)

机构地区：[1]太极集团重庆中药二厂有限公司,重庆402260 [2]重庆太极实业(集团)股份有限公司,重庆408000

出　　处：《现代工程科技》2023年第12期55-58,共4页Modern Engineering Technology

摘　　要：通过实验探索研究复方板蓝根颗粒浓缩生产过程,在执行现有制法标准的情况下,发现稠膏密度及过滤温度等因素会影响稠膏溶化性,最终确定醇沉前药液相对密度1.20(80℃),醇沉后稠膏浓缩至相对密度1.18~1.22(75℃),稠膏过滤温度不超过30℃,稠膏用100目筛网过滤,根据优化后的参数生产出的稠膏溶化性合格且放置一段时间后仍然合格,从而保证复方板蓝根颗粒溶化性质量指标,给患者良好的感受,推动中药颗粒剂产业的高质量发展。Through experimental exploration and research on the concentration production process of compound Banlangen granules,it was found that factors such as the density of the thick paste andfiltration temperature can affect the solubility of the thick paste,and the relative density of the drug solution before alcohol precipitation was 1.20(80℃).After alcohol precipitation,the thick paste was concentrated to a relative density of 1.18-1.22(75℃),and thefiltration temperature of the thick paste did not exceed 30℃.The thick paste wasfiltered using a 100 mesh sieve,The thick paste produced based on the optimized parameters has a qualified solubility and is still qualified after being placed for a period of time,thereby ensuring the solubility quality index of compound Banlangen granules,giving patients a good feeling,and promoting the high-quality development of the traditional Chinese medicine granule industry.

关 键 词：复方板蓝根颗粒 溶化性 温度 相对密度 过滤 

分 类 号：R283.6[医药卫生—中药学]