CircRNA通过铁死亡参与调控疾病发生发展的研究进展  

Research progress on the role of circRNA in diseases through targeting ferroptosis

作　　者：常琳 王莹[2] 程文政 杨晨旭 许超千[3] CHANG Lin;WANG Ying;CHENG Wen-Zheng;YANG Chen-Xu;XU Chao-Qian(College of Pharmacy,Mudanjiang Medical University,Mudanjiang 157400,China;College of Basic Medicine,Mudanjiang Medical University,Mudanjiang 157400,China;College of Pharmacy,Harbin Medical University,Harbin 150081,China)

机构地区：[1]牡丹江医学院药学院,牡丹江157400 [2]牡丹江医学院基础医学院,牡丹江157400 [3]哈尔滨医科大学药学院,哈尔滨150081

出　　处：《生命科学》2023年第8期1023-1033,共11页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(30600760,3097-3541);神经变性病教育部重点实验室开放课题(2013-SJBX01)。

摘　　要：环状RNA(circular non-coding RNA,circRNA)是一类特殊的非编码RNA分子,呈封闭环状结构,不易受核糖核酸外切酶(ribonuclease R,RNaseR)影响,表达更稳定且不易降解。CircRNA可在转录后水平调控基因表达,从而广泛参与多种生理病理过程。铁死亡是一种铁依赖性、由脂质过氧化引起的新型程序性细胞死亡方式。研究表明,circRNA可以通过调控细胞铁死亡,在癌症、糖尿病并发症、心脑血管疾病、呼吸系统疾病中发挥重要作用。本文通过综述circRNA在不同疾病中调控细胞铁死亡的作用及机制,为相关疾病的治疗提供新的靶点和思路。Circular RNA(circular non-coding RNA,circRNA),a special kind of non-coding RNA with closed circular structure,is more stable and not easy to be digested by ribonuclease R(RNaseR).It is involved in the regulation of gene expression at post-transcriptional level in multiple biological processes including ferroptosis,which is a new type of iron-dependent programmed cell death caused by lipid peroxidation.Studies have shown that circRNAs play an important role in cancer,diabetic complications,cardio-cerebrovascular diseases and respiratory diseases by regulating ferroptosis.In this paper,we review the role and mechanism of circRNA in regulating ferroptosis in different diseases,aiming to provide new therapeutic targets and ideas.

关 键 词：circRNA 铁死亡 肿瘤 心脑血管疾病 

分 类 号：Q522[生物学—生物化学]