细胞周期停滞标志物在AKI的诊断及预后中的研究进展  

Advances in research on biomarkers of cell cycle arrest in diagnosis and prognosis of acute kidney injury

作　　者：易香伶 罗佳 陈客宏 陈佳 何娅妮 YI Xiang-Ling;LUO Jia;CHEN Ke-Hong;CHEN Jia;HE Ya-Ni(Army Medical Center of PLA,Chongqing 400042,China)

机构地区：[1]陆军特色医学中心,重庆400042

出　　处：《生命科学》2023年第8期1089-1097,共9页Chinese Bulletin of Life Sciences

基　　金：重庆市科卫联合医学科研项目青年项目(2023QNXM011);第三军医大学创伤、烧伤与复合伤国家重点实验室项目(SKLKF202202);陆军军医大学科技创新能力提升专项项目青年培育项目(2019XQN15)。

摘　　要：急性肾损伤(acute kidney injury,AKI)是住院患者常见且严重的并发症,目前临床上缺乏AKI早期诊断及预后评估的生物标志物。近期研究表明,细胞周期停滞在AKI发生发展中发挥重要作用,其生物标志物金属蛋白酶组织抑制因子2(tissue inhibitor of metalloproteinase 2,TIMP2)和胰岛素样生长因子结合蛋白7(insulin-like growth factor binding protein 7,IGFBP7)可用于早期诊断AKI及预后评估。该文对细胞周期停滞在AKI中的作用机制进行论述,为干预细胞周期停滞改善AKI预后提供潜在治疗靶点;同时对细胞周期停滞标志物TIMP2和IGFBP7在AKI中的研究进行综述,为AKI早期诊断及预后评估提供潜在生物标志物。Acute kidney injury(AKI)is a common and severe complication in hospitalized patients.Currently,biomarkers for early diagnosis and prognosis of AKI are lacking in clinic.Recent studies have shown that cell cycle arrest plays an important role in the occurrence and development of AKI,and the biomarkers tissue inhibitor of metalloproteinase 2(TIMP2)and insulin-like growth factor binding protein 7(IGFBP7)can be used for early diagnosis and prognosis of AKI.This review described the mechanism of cell cycle arrest in AKI,which will provide potential therapeutic targets for intervening cell cycle arrest to improve the prognosis of AKI.Meanwhile,the studies on cell cycle arrest markers TIMP2 and IGFBP7 in AKI were referred,which will provide potential biomarkers for the early diagnosis and prognosis of AKI.

关 键 词：细胞周期停滞 急性肾损伤 生物标志物 金属蛋白酶组织抑制因子2 胰岛素样生长因子结合蛋白7 

分 类 号：Q253[生物学—细胞生物学] R692[医药卫生—泌尿科学]