中药复方提取物对槟榔所致大鼠急性炎症的影响  

Effects of plant extract and betel nut on acute inflammation in rats

作　　者：宋晓慧 朱珺玎 李智 马朝阳[1,3] 王洪新 SONG Xiaohui;ZHU Junding;LI Zhi;MA Chaoyang;WANG Hongxin(School of Food Science and Technology,Jiangnan University,Wuxi,Jiangsu 214122,China;Hunan Wuzizui Industrial Group Co.,Ltd.,Xiangtan,Hunan 411100,China;National Engineering Research Center for Functional Food,Jiangnan University,Wuxi,Jiangsu 214122,China)

机构地区：[1]江南大学食品学院,江苏无锡214122 [2]湖南伍子醉实业集团有限公司,湖南湘潭411100 [3]国家功能食品工程技术研究中心〔江南大学〕,江苏无锡214122

出　　处：《食品与机械》2023年第8期142-146,226,共6页Food and Machinery

基　　金：国家食品科学与工程一流学科建设项目(编号:JUFSTR20180204)。

摘　　要：目的:减弱槟榔造成的炎症损伤,降低食用风险。方法:选择甘草、桔梗、枇杷叶3种中药材,以低、中、高剂量添加并与槟榔提取物共同灌胃大鼠28 d后,在大鼠足跖注射致炎剂,与空白对照组和阳性对照组大鼠比较体重、脏器系数、6 h内足跖肿胀率及炎症因子和炎症介质水平。结果:高剂量组相较于槟榔组可以显著(P<0.05)降低炎症介质前列腺素E_(2)(PGE_(2))、丙二醛(MDA)和一氧化氮(NO)的产生,下调血清促炎因子肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)水平以及促进白细胞介素-10(IL-10)的释放,并减少肝脏中活性氧(ROS)的产生,且大鼠足跖肿胀率明显(P<0.05)低于空白对照组,与阳性对照组相近。结论:添加多种具有抗炎功效的天然植物提取物与槟榔共同使用可在一定程度上减轻因槟榔加剧的大鼠急性炎症。Objective:This study aimed to reduce inflammation effect caused by long-term and large amount of betel nut chewing.Methods:Natural plant extracts with anti-inflammatory effects were added to betel nut in order to reduce the inflammatory damage.Glycyrrhiza uralensis fisch,radix platycodi and loquat leaf were used to treat rats with areca nut for 28 days.Body weight,organ coefficient,swelling rate of plantar in 6 hours,levels of inflammatory factors,and mediators were compared.Results:The addition of high-dose natural plant extract significantly reduced the production of prostaglandin E_(2)(PGE_(2)),malondialdehyde(MDA),and nitric oxide(NO)compared to betel nut used group.Less pro-inflammatory tumor necrosis factor(TNF-α),interleukin-1β(IL-1β),interleukin-6(IL-6)and more release of interleukin-10(IL-10)were observed.It also reduced the production of reactive oxygen species(ROS)in the liver.The swelling rate of rats'feet(P<0.05)was significantly lower than the control group,and similar to the positive control group.Conclusion:The addition of natural plant extracts with anti-inflammatory effect can reduce the acute inflammation in rats,and provide a new development idea for the further processing of areca catechu.

关 键 词：槟榔 甘草 桔梗 枇杷叶 急性炎症 大鼠足跖肿胀 炎症因子 

分 类 号：R285.5[医药卫生—中药学]