电纺PLLA/PCL复合纤维及其性能研究综合实验设计  

Comprehensive experimental design of study on electrospun PLLA/PCL composite fibers and properties

作　　者：史同娜[1] 朱冰洁[1] 施镇江[1] 谢卫民 吴文华[1] SHI Tongna;ZHU Bingjie;SHI Zhenjiang;XIE Weimin;WU Wenhua(National Experimental Teaching Demonstration Center for Materials Science and Engineering,Donghua University,Shanghai 201620,China;Shanhai Wanxin Computer Information Technology CO.,Ltd.,Shanghai 200083,China)

机构地区：[1]东华大学材料科学与工程国家级实验教学示范中心,上海201620 [2]上海万欣计算机信息科技有限公司,上海200083

出　　处：《实验技术与管理》2023年第7期49-55,共7页Experimental Technology and Management

基　　金：国家自然科学基金资助项目(52073049)。

摘　　要：电纺左旋聚乳酸(PLLA)/聚己内酯(PCL)复合纤维综合实验的设计是教研结合初探的产物。该文通过静电纺丝法制备了PLLA/PCL复合纤维,对纤维的形貌、化学结构、结晶和体外降解性能进行了一系列表征测试及胆管上皮细胞的相容性实验,讨论了组分配比对复合纤维形貌和结晶性能的影响,分析了复合纤维的降解趋势。细胞相容性实验证实了PLLA/PCL复合纤维适合胆管上皮细胞的生长,并初步探讨了PLLA/PCL复合纤维在组织工程人工胆管支架材料领域的应用前景。该综合实验可以培养学生的创新意识,激发学生的科研兴趣,提升学生的科学研究和实践能力。Comprehensive experimental design of electrospun L-polylactic acid(PLLA)/polycaprolactone(PCL)composite fibers is the product of the combination of teaching and research.In this paper,PLLA/PCL disordered fibers are prepared by electrostatic spinning method,the characterizations such as the morphology,chemical structure,crystallization of fibers are tested and the cell compatibility experiment is done.The influence of component ratios on the morphology and crystallization of the composite fibers is discussed,and the degradation trend of the composite fibers is analyzed.The possibility of PLLA/PCL fibrous scaffolds applied in the field of tissue-engineering bile duct is discussed.Cell compatibility experiments have confirmed that PLLA/PLC composite fibers are suitable for the growth of biliary epithelial cells.The possibility of PLLA/PCL fibrous scaffolds applied in the field of tissue-engineering bile duct is discussed.The comprehensive experiment can cultivate students'innovative consciousness,stimulate students’interest in scientific research,and improve their ability of scientific research and practical application.

关 键 词：左旋聚乳酸 聚己内酯 静电纺丝 复合纤维 胆管支架材料 

分 类 号：TB324[一般工业技术—材料科学与工程]