NLRP3炎症小体:化学性肝损伤防治靶点  

NLRP3 Inflammasome:a target for prevention and treatment of chemical liver injury

作　　者：董颖 李纪丰 张宇欣 郭浩林 白婷 杨勇 DONG Ying;LI Jifeng;ZHANG Yuxin;GUO Haolin;BAI Ting;YANG Yong(Dalian University Dalian Key Laboratory of Chronic Disease Research Center)

机构地区：[1]大连大学慢性病研究中心大连市重点实验室,辽宁大连116622

出　　处：《中国药理学与毒理学杂志》2023年第9期703-710,共8页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(81900532);国家自然科学基金(81700523);中央引导地方科技发展资金自由探索类基础研究项目。

摘　　要：近年来,化学性肝损伤的发生率居高不下,也是肝功能衰竭和死亡的关键原因之一,然而其确切的机制尚未阐明,治疗选择非常有限。研究表明,核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)炎症小体作为研究最广泛的炎症体,其诱导的炎症反应在化学性肝损伤的发展中起关键作用。因此,在化学性肝损伤的药物治疗中,靶向NLRP3炎症小体可能是一种很有前途的方法。天然产物可通过靶向NLRP3炎症小体发挥清除自由基、抑制脂质过氧化作用,进而抑制炎症因子的表达,阻止细胞焦亡,对多种化学物质诱导的肝损伤起到预防和治疗作用。In recent years,the incidence of chemical liver injury has remained high as one of the key causes of liver failure and death.However,the exact mechanisms are not fully understood and treatment options are quite limited.Recent studies have shown that NOD-like receptor protein 3(NLRP3),as the most widely studied inflammasome,induces inflammatory response and plays a key role in the development of chemical liver injury.Therefore,targeting this inflammasome may be a promising pharmacological approach to chemical liver injury.Natural products are capable of clearing free radicals and inhibiting lipid peroxidation by targeting the NLRP3 inflammasome,thereby inhibiting the expressions of inflammatory factors and preventing pyroptosis.These products can help prevent and treat liver injury induced by a variety of chemical substances.

关 键 词：NLRP3炎症小体 化学性肝损伤 信号通路 天然产物 

分 类 号：R963[医药卫生—微生物与生化药学]