硅沉着病患者和实验模型动物不同生物样本中氧化应激生物标志物及其应用研究进展  

Research progress in oxidative stress biomarkers in different biological samples of silicosis patients and experimental model animals and their applications

作　　者：唐蒙 刘静 曾明[1] TANG Meng;LIU Jing;ZENG Ming(Department of Health Toxicology,Xiangya School of Public Health,Central South University,Changsha 410078,China;Tongxiang Center for Disease Control and Prevention,Jiaxing 314599,China;Chongqing Jiulongpo District Center for Disease Control and Prevention,Chongqing 400050,China)

机构地区：[1]中南大学湘雅公共卫生学院卫生毒理学系,湖南长沙410078 [2]嘉兴市桐乡市疾病预防控制中心,浙江嘉兴314599 [3]重庆市九龙坡区疾病预防控制中心,重庆400050

出　　处：《中国药理学与毒理学杂志》2023年第9期719-724,共6页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(81673225)。

摘　　要：硅沉着病(矽肺)是在生产环境中长期吸入游离二氧化硅(SiO_(2))含量较高的粉尘(又称矽尘)导致肺部广泛结节性纤维化为主的疾病,随着纤维化的发展逐渐损害肺功能。研究表明,氧化应激是硅沉着病发病的重要机制。在硅沉着病患者或实验动物模型的不同生物样本中存在许多氧化应激生物标志物,其对硅沉着病的发生发展可能具有重要诊断和治疗价值。本文对硅沉着病患者或实验模型动物的血液、尿液、肺组织、呼出气体及支气管肺泡灌洗液中氧化应激标志物的类型、潜在生物学意义、以及优点和局限性进行综述,为其可能应用于临床实践和设定职业暴露限值提供新的方向和线索。Silicosis is a disease characterized by widespread nodular fibrosis of the lungs due to long-term inhalation of dust with a high free silica content(also known as silica dust) in a manufacturing environment,which gradually impairs lung function as the fibrosis progresses.Studies have shown that oxidative stress is an important mechanism in the pathogenesis of silicosis.Many markers of oxidative stress exist in different biomaterials from patients with silicosis or experimental animals,and these markers may be of great value in the development of silicosis.This paper reviews the types,potential biological significance,advantages and limitations of oxidative stress markers in biological specimens from patients with silicosis or experimental animals in order to provide new perspectives on and clues to their possible applications in clinical practice and in setting occupational exposure limits.

关 键 词：硅沉着病 SiO_(2)粉尘 氧化应激 生物标志物 

分 类 号：R563.9[医药卫生—呼吸系统] R446.1[医药卫生—内科学]