活血化瘀类中药注射剂不良反应的汇总分析  

Adverse Drug Reactions Analysis of Traditional Chinese Medicine Injections for Promoting Blood Circulation and Removing Blood Stasis:A Pooled Analysis

作　　者：刘丹 许长青 LIU Dan;XU Chang Qing(Department of Pharmacy,Beijing Armed Police Corps Hospital,Beijing 100027,China)

机构地区：[1]武警北京市总队医院药剂科,北京100027

出　　处：《中国医药指南》2023年第26期124-126,共3页Guide of China Medicine

摘　　要：目的通过对活血化瘀类中药注射剂所致不良反应的文献进行汇总分析,为促进临床安全合理用药提供参考。方法以“活血化瘀”“不良反应”“中药注射剂”为检索词,检索中国知网全中文数据库、万方中文期刊全文数据库,按纳入与排除标准筛选出22篇文献,分析文献并提取相关病例归纳分析。结果共提取病例569例,男性236例(41.5%)不良反应发生于从幼儿到成人各年龄段,多发于41~60岁年龄段,累及系统-器官损害主要为皮肤及其附件系统、消化系统和神经系统、心血管系统及泌尿系统,不良反应以皮疹、腹胀腹泻及头痛等较为常见。药物中不良反应比例最高的是血塞通注射液(50.4%),其次是丹参多酚酸盐注射液(17.9%)、丹红注射液(17.2%)。结论活血化瘀类中药注射剂的不良反应常见于中老年人,药物最常见的是血塞通注射液,最常累及的部位是皮肤及其附件,其次是消化系统和神经系统。临床应加强相关药学监护,确保患者用药安全。Objective To analyze of the adverse reactions caused by TCM injections for promoting blood circulation and removing blood stasis by retrieving literature,and provide reference for promoting clinical safe and rational drug use.Methods Using"promoting blood circulation and removing blood stasis","adverse reactions"and"TCM injection"as search terms,the whole Chinese database of CNKI and Wanfang database were searched,and 22 literatures were screened out according to inclusion and exclusion criteria,and the literatures were analyzed and related cases were extracted for analysis.Results A total of 569 cases with adverse drug reaction were included.Adverse reactions occurred in all ages from children to adults,mostly in the age range of 41-60 years,and the involved system-organ damage was mainly the skin and its accessory system,digestive and nervous system,etc.Adverse reactions were more common with rash,abdominal distension,diarrhea and headache.Conclusions The adverse reactions of TCM injections for promoting blood circulation and removing blood stasis were common,and clinical pharmaceutical care should be strengthened to ensure the medication safety of patients.

关 键 词：活血化瘀 不良反应 中药注射剂 

分 类 号：R282.7[医药卫生—中药学]