补肾序贯疗法结合活血化瘀方加减治疗子宫内膜异位症所致痛经临床研究  

Clinical Study on Treating Dysmenorrhea Caused by Endometriosis with Kidney-Tonifying Sequential Therapy Combined with Modified Formula for Promoting Blood Circulation and Removing Blood Stasis

作　　者：俞璐沁 张敏娟 杨琼艳 徐隽斐[3] YU Luqin;ZHANG Minjuan;YANG Qiongyan;XU Junfei(OB/GYN Hospital of Fudan University,Shanghai,China,200090;Shanghai Municipal Hospital of Traditional Chinese Medicine,Shanghai,China,200000;Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China,200021)

机构地区：[1]复旦大学附属妇产科医院,上海200090 [2]上海市中医医院,上海200000 [3]上海中医药大学附属曙光医院,上海200021

出　　处：《河南中医》2023年第9期1375-1379,共5页Henan Traditional Chinese Medicine

基　　金：上海市科学技术委员会科研计划项目(18701103754)。

摘　　要：目的:观察补肾序贯疗法结合活血化瘀方加减治疗子宫内膜异位症所致痛经的临床疗效。方法:选取复旦大学附属妇产科医院妇科2021年2月至2022年2月收治的子宫内膜异位症所致痛经患者110例,按照随机数字表法分为对照组和观察组,每组55例。对照组于月经周期的1~5 d给予醋酸曲普瑞林注射液静脉注射治疗,观察组于不同月经时期给予补肾序贯疗法结合活血化瘀方加减治疗。比较两组临床疗效,观察两组患者治疗前后血清人8异前列腺素(8-epi-prostaglandin F2 alpha,8-iso-PGF2α)、催产素(oxytocin,OT)、糖类抗原(cancer associated antigen125,CA125)、神经生长因子(nerve growth factor,NGF)、前列腺素E_(2)(prostaglandin E_(2),PGE_(2))、前列腺素F_(2α)(prostaglandin F_(2α),PGF_(2α))水平及疼痛程度和兼症改善情况评分。结果:观察组有效率为90.91%,对照组有效率为70.91%,观察组有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后痛经程度、兼症改善情况评分低于对照组,差异有统计学意义(P<0.05);观察组治疗后血清8-iso-PGF2α、OT、CA125水平低于对照组,差异有统计学意义(P<0.05);观察组治疗后血清NGF、PGF_(2α)、PGE_(2)水平低于对照组,差异有统计学意义(P<0.05)。结论:补肾序贯疗法结合活血化瘀方加减可减少子宫内膜异位症所致痛经患者疼痛症状,改善内分泌环境,降低血清8-iso-PGF2α、OT、CA125、NGF、PGF_(2α)、PGE_(2)水平。Objective:To observe the clinical efficacy of kidney-tonifying sequential therapy combined with Modified Formula for Promoting Blood Circulation and Removing Blood Stasis on dysmenorrhea caused by endometriosis.Methods:A total of 110 patients with dysmenorrhea caused by endometriosis admitted to the Gynecology Department of OB/GYN Hospital of Fudan University from February 2021 to February 2022 were divided into the control group and the observation group according to the random number table method,with 55 cases in each group.The control group was given Triprerelin Acetate Injection intravenously on the lst to 5th day of the menstrual cycle,while the observation group was given kidney-tonifying sequential therapy combined with Modified Formula for Promoting Blood Circulation and Removing Blood Stasis.The clinical efficacy was compared between the two groups.The serum human 8-epi-prostaglandin F2 alpha(8-iso-PGF_(2α)),oxytocin(OT),and cancer associated antigen125(CA125),nerve growth factor(NGF),prostaglandin E_(2)(PGE_(2)),prostaglandin F_(2a)(PGF_(2a))level,pain degree and accompanying symptoms'improvement score before and after treatment in the two groups were observed.Results:The effective rate was 90.91%in the observation group and 70.91%in the control group,and the effective rate in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).After treatment,the degree of dysmenorhea and the improvement of accompanying symptoms in the observation group were lower than those in the control group,and all the differences were statistically significant(P<0.05);The serum levels of 8-iso-PGF_(2α),OT and CA125 in the observation group were lower than those in the control group,and allthe differences were statistically significant(P<0.05);The levels of serum NGF,PGF_(2a)and PGE_(2)in the observation group were lower than those in the control group,and allthe differences were statistically significant(P<0.05).Conclusion:Kidney-tonifying sequential therapy combi

关 键 词：痛经 子宫内膜异位症 补肾序贯疗法 活血化瘀方 滋阴方 补阳方 

分 类 号：R271.113[医药卫生—中医妇科学]