三维细胞模型在抗癌药物筛选中的研究进展  

Research Progress of 3D Cell Model in Anti-cancer Drug Screening

作　　者：孙雅倩 SUN Yaqian(Faculty of Environment and Life Sciences,Beijing University of Technology,Beijing 100021,China)

机构地区：[1]北京工业大学环境与生命学部,北京100021

出　　处：《现代诊断与治疗》2023年第11期1629-1631,共3页Modern Diagnosis and Treatment

摘　　要：目前大多数临床前抗癌药物的筛选主要依赖于传统的二维细胞培养技术(2D cell culture),然而,二维细胞培养技术无法模拟体内肿瘤微环境,更无法体现实体肿瘤特性,对药物活性的预测能力相对较差。三维细胞培养技术(3D cell culture)是介于二维细胞培养和动物实验之间的一种技术,既能更好的反应体内生物学状态,又能减少动物实验的消耗。三维细胞培养可以将单层细胞的个体研究与生物体的整体研究联系起来,可以在体外更大程度地再现体内细胞的生物表型,进而可以更精确地预测抗肿瘤药物的活性和药效。At present,most of the screening of preclinical anticancer drugs mainly relies on traditional 2D cell culture.However,this traditional technology cannot simulate the tumor microenvironment in vivo,nor can it reflect the characteristics of solid tumor,and its ability in predicting drug activity is relatively poor.The 3D cell culture is a technology between 2D cell culture and animal experiments,which can better reflect the biological state in vivo and reduce the consumption of animal experiments.The 3D cell culture can link the individual study of monolayer cells with the study of the whole organism,reproduce in vitro the biological phenotype of cells in vivo to a greater extent,and can thus predict the activity and efficacy of anti-tumor drugs more accurately.

关 键 词：三维细胞培养技术 药物活性 癌症研究 

分 类 号：R979.1[医药卫生—药品]