脂蛋白a致冠心病相关机制的研究进展  

Research Progress in the Mechanism of Coronary Heart Disease Induced by Lipoprotein-a

作　　者：王宇 杨帆[1] 孙林[1] WANG Yu;YANG Fan;SUN Lin(Department of Cardiology,The Second Affiliated Hospital of Kunming Medical University,Kunming 650106,Yunnan,China)

机构地区：[1]昆明医科大学第二附属医院心内科,云南昆明650106

出　　处：《现代诊断与治疗》2023年第11期1631-1635,共5页Modern Diagnosis and Treatment

摘　　要：冠心病的发病率和死亡率逐年上升,严重危害国民健康,脂质代谢紊乱是主要危险因素。作为脂质家族一员的脂蛋白a[Lp(a)]近些年被证实为冠心病的独立危险因素,但尚未清楚Lp(a)如何促进冠心病的发生发展。本文主要综述Lp(a)结构、代谢、遗传并从募集炎症细胞、促进血栓形成、促进动脉粥样硬化等方面阐释Lp(a)对冠心病的作用机制。The morbidity and mortality of coronary heart disease are increasing year by year,which seriously endangers the national health.Lipid metabolism disorder is the main risk factor.As a member of lipid family,Lipoprotein-a[Lp(a)]has been proved to be an independent risk factor of coronary heart disease in recent years,while it remains unclear how Lp(a)promotes the occurrence and development of coronary heart disease.This article mainly reviews the structure,metabolism and genetics of Lp(a),and explains the mechanism of Lp(a)on coronary heart disease from the aspects of recruiting inflammatory cells,promoting thrombosis,and promoting atherosclerosis.

关 键 词：冠心病 脂蛋白A 机制 

分 类 号：R541.4[医药卫生—心血管疾病]