YBX2-dependent stabilization of oocyte mRNA through a reversible sponge-like cortical partition  

作　　者：Zhihua Zhang Ruyi Liu Hongbin Zhou Yuxi Luo Jian Mu Jing Fu Tianyu Wu Biaobang Chen Qing Sang Lei Wang 

机构地区：[1]Institute of Pediatrics,Children’s Hospital of Fudan University,the Institutes of Biomedical Sciences,The State Key Laboratory of Genetic Engineering,School of Life Sciences,Fudan University,Shanghai,China [2]Shanghai Ji Ai Genetics and IVF Institute,Obstetrics and Gynecology Hospital,Fudan University,Shanghai,China [3]NHC Key Lab of Reproduction Regulation(Shanghai Institute for Biomedical and Pharmaceutical Technologies),Fudan University,Shanghai,China

出　　处：《Cell Research》2023年第8期640-643,共4页细胞研究（英文版）

基　　金：the National Natural Science Foundation of China(82288102);the National Key R&D Program for Young Scientists(2022YFC2702300);the National Key R&D Program of China(2021YFC2700100);the National Natural Science Foundation of China(32130029,82171643,81971450,82001538,81971382).

摘　　要：Dear Editor,Oocyte meiotic maturation and early embryogenesis occur in the absence of transcription and rely on maternal mRNA stored in oocytes.Inmice,thetranscription is subsequently silenced from the late germinal vesicle(GV),stage until embryonic genome activation at the 2-cell stage.1 Therefore,during early oocyte growth,the oocyte must accumulate essential mRNA transcripts to support subsequent oocyte maturation,meiosis,and early embryo development.The growth period of mouse oocytes is usually 22-24 days,and the mRNA synthesized and stored during this time is remarkably stable with a half-life of nearly 2 weeks.2 In contrast,the half-life of most mRNA in mouse embryonic stem cells is less than 24 h.3 Thus,the exact mechanism for how the maternal mRNA in oocytes,maintains their long-term stability remainsunclear.

关 键 词：PARTITION STABILIZATION SPONGE 

分 类 号：Q2[生物学—细胞生物学]