卡托普利在小儿急性肾炎高血压患儿中的应用效果  

Effect of Captopril on Hypertension in Children with Acute Nephritis

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作  者:刘馨 周艳[2] Liu xin;Zhou Yan(Guihang Guiyang Hospital,Guiyang 550009,Guizhou Province,China;Guiyang Maternal and Child Health Care Hospital,Guiyang 550001,Guizhou Province,China)

机构地区:[1]贵航贵阳医院,贵州贵阳550009 [2]贵阳市妇幼保健院,贵州贵阳550001

出  处:《中外医药研究》2023年第11期27-29,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘  要:目的:分析卡托普利治疗小儿急性肾炎高血压的效果。方法:选取2021年1月—2022年12月贵阳市妇幼保健院收治的小儿急性肾炎高血压患儿129例为研究对象,依据随机数字表法分对照组(64例)、观察组(65例)。对照组予以硝苯地平缓释片,观察组予以卡托普利,对比疗效。结果:治疗后,观察组患儿收缩压、舒张压低于对照组,差异有统计学意义(P<0.001);治疗后,两组患儿血肌酐、尿素氮、24h尿蛋白、尿红细胞水平均降低,观察组低于对照组,差异有统计学意义(P<0.05);观察组患儿血压恢复正常、水肿改善、尿少改善、血尿消失时间短于对照组,差异有统计学意义(P<0.001);治疗后,观察组患儿白细胞、白介素-6、肿瘤坏死因子、C反应蛋白水平低于对照组,差异有统计学意义(P<0.001);观察组患儿不良反应发生率低于对照组,差异有统计学意义(P=0.049)。结论:小儿急性肾炎高血压以卡托普利治疗降压效果显著,且有利于促进肾功能及相关症状改善,不容易引起不良反应。Objective:To analyze the effect of captopril in the treatment of hypertension in children with acute nephritis.Methods:A total of one hundred and twenty-nine children with acute nephritis and hypertension admitted to Guiyang Maternal and Child Health Care Hospital from January 2021 to December 2022 were selected as the study objects,and were divided into control group(64 cases)and observation group(65 cases)according to random number table method.The control group was given nifedipine sustained-release tablets,and the observation group was given captopril.The curative effect was compared.Results:After treatment,systolic blood pressure and diastolic pressure in observation group were significantly lower than those in control group(P<0.001);After treatment,the levels of serum creatinine,urea nitrogen,24 h urinary protein and urinary red blood cells in 2 groups were decreased,and the observation group was lower than the control group,the difference was statistically significant(P<0.05);Blood pressure returned to normal,edema improved,oliguria improved,and hematuria disappeared for a shorter time in observation group than control group,the difference was statistically significant(P<0.001);After treatment,the levels of leukocyte,interleukin-6,tumor necrosis factor and C-reactive protein in observation group were lower than those in control group,with statistical significance(P<0.001);The incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P=0.049).Conclusion:The treatment of acute nephritis hypertension in children with captopril has significant antihypertensive effect,and is conducive to promoting the improvement of renal function and related symptoms,and is not easy to cause adverse reactions.

关 键 词:小儿急性肾炎 高血压 卡托普利 血压 肾功能指标 炎性因子 不良反应 

分 类 号:R54[医药卫生—心血管疾病]

 

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