2,3-Seco and 3-nor guaianolides from Achillea alpina with antidiabetic activity  

作　　者：XUE Guimin ZHAO Chenguang XUE Jinfeng DUAN Jiangjing PAN Hao ZHAO Xuan YANG Zhikang CHEN Hui SUN Yanjun FENG Weisheng 

机构地区：[1]College of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China

出　　处：《Chinese Journal of Natural Medicines》2023年第8期610-618,共9页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.82003606);the Scientific and Technological Key Project in Henan Province(No.212102311093);the Scientific Research Nursery Project(No.MP2020-29).

摘　　要：In this study,we presented the isolation and characterization of eight novel seco-guaianolide sesquiterpenoids(1-8)and two known guaianolide derivatives(9 and 10),from the aerial part of Achillea alpina L..Compounds 1-3 were identified as guaianolides bearing an oxygen insertion at the 2,3 position,while compounds 4-8 belonged to a group of special 3-nor guaianolide sesquiterpenoids.The structural elucidation of 1-8,including their absolute configurations,were accomplished by a combination of spectroscopic data analysis and quantum electronic circular dichroism(ECD)calculations.To evaluate the potential antidiabetic activity of compounds 1-10,we investigated their effects on glucose consumption in palmitic acid(PA)-mediated HepG2-insulin resistance(IR)cells.Among the tested compounds,compound 7 demonstrated the most pronounced ability to reverse IR.Moreover,a mechanistic investigation revealed that compound 7 exerted its antidiabetic effect by reducing the production of the pro-inflammatory cytokine IL-1β,which was achieved through the suppression of the NLRP3 pathway.

关 键 词：Achillea alpina Seco-guaianolide Glucose consumption Antidiabetic activity 

分 类 号：R284.1[医药卫生—中药学]