基于肿瘤相关巨噬细胞探讨中医药治疗三阴性乳腺癌特色及研究进展  

Exploration on characteristics and research progress of traditional Chinese medicine in treatment of triple⁃negative breast cancer based on tumor⁃associated macrophages

作　　者：高阳 史有阳 陈利利 郑懿 刘胜[2] 周细秋[1] GAO Yang;SHI Youyang;CHEN Lili;ZHENG Yi;LIU Sheng;ZHOU Xiqiu(Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]上海中医药大学,上海201203

出　　处：《上海中医药大学学报》2023年第4期90-94,共5页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：上海市科委科研基金资助项目(20Z21900300)。

摘　　要：三阴性乳腺癌(TNBC)因缺乏内分泌及靶向治疗的作用靶点,因此与其他类型乳腺癌相比,TNBC具有侵袭力强、耐药性高的危害。肿瘤相关巨噬细胞(TAMs)是肿瘤微环境(TME)中最丰富的细胞,极化而成的经典M1型和可选择性的M2型分别具有抗肿瘤活性和促肿瘤活性。近年来研究发现,TAMs在TNBC发生发展过程中扮演着重要角色,可促进TNBC增殖,促进TNBC迁移和侵袭,促进TNBC肿瘤血管形成,促进TNBC免疫抑制与逃逸。相关研究提示,中药有效成分或复方可增强TAMs的吞噬功能进而推动TAMs极化为M1型,可促进M2型复极化为M1型,可抑制TAMs极化为M2型,中医药通过调节TAMs极化干预TNBC的优势逐渐被发现,其在TNBC的治疗中发挥着重要作用。Compared with other types of breast cancer,triple-negative breast cancer(TNBC)has strong invasion and high drug resistance,due to the lack of targets of endocrine and targeted therapy.Tumor-associated macrophages(TAMs)are the most abundant cells in the tumor microenvironment(TME).The classic M1 type and the selective M2 type polarized by TAMs have anti-tumor and pro-tumor activities,respectively.The studies of recent years find that TAMs play an important role in the occurrence and development of TNBC,which can promote the proliferation of TNBC,the migration and invasion of TNBC,the formation of tumor vessels of TNBC,and the immunosuppression and escape of TNBC.The correlative studies indicate that the active components or compounds of traditional Chinese medicine can enhance the phagocytic function of TAMs,further promote the polarization of TAMs into M1 type,promote the repolarization of M2 type into M1 type,and inhibit the polarization of TAMs into M2 type.The advantages of traditional Chinese medicine in TNBC intervention by regulating the polarization of TAMs have been gradually found,and it plays an important role in the treatment of TNBC.

关 键 词：三阴性乳腺癌 肿瘤相关巨噬细胞极化 中医药 

分 类 号：R273[医药卫生—中西医结合]