网络药理学研究现状及在化妆品领域应用展望  

Research status of network pharmacology and its application prospect in the field of cosmetics

作　　者：孙锦月 何聪芬[1] Jinyue Sun;Congfen He(Beijing Key Laboratory of Plant Resources Research and Development,School of Chemistry and Materials Engineering,Beijing Technology and Business University,Beijing 100048,China)

机构地区：[1]北京工商大学化学与材料工程学院植物资源研究开发北京市重点实验室,北京100048

出　　处：《日用化学工业（中英文）》2023年第9期1087-1093,共7页China Surfactant Detergent & Cosmetics

摘　　要：网络药理学的出现是当前人工智能和大数据时代发展的结果,对医药领域疾病的治疗和新药的研发起着十分重要的作用,但未有关于网络药理学在化妆品领域中的相关应用研究。本文从药理学及中医药研究、复杂性疾病揭示、药物创制等几个方面回顾和梳理了网络药理学应用研究的发展现状,并对未来网络药理学在化妆品植物功效原料的选择、化妆品功效性评价、化妆品安全性评价三方面提出了应用设想。The emergence of cyberpharmacology is the result of the current development of artificial intelligence and big data era,which plays a very important role in the treatment of diseases and the development of new drugs in the field of medicine,and is currently mainly used to reveal the mechanism of action of drugs in the body to treat diseases and guide the use of drugs.The mechanism of action on the skin is similar to the action of Chinese medicine on the body in the field of medicine,but there is no research on the application of network pharmacology in the field of cosmetics.In this paper,we review the current development of applied research in cyberpharmacology from the aspects of pharmacology and Chinese medicine research,complex disease discovery,and drug creation,and propose the future application of cyberpharmacology in the selection of cosmetic botanical efficacy ingredients,cosmetic efficacy evaluation,and cosmetic safety evaluation.It is pointed out that skin-related targets,such as sensitive skin-related inflammatory targets:TNF-α,IL-1α,IL-1β,IL-8,TRPV1;whitening-related targets:TYR,TRP-1,TRP-2;acne-related anti-inflammatory and antibacterial targets,etc.,can be used to screen herbal ingredients for cosmetic products and guide the development of formulations to achieve precise skin care.Network pharmacology can also be applied to the phyto-effective ingredients in the existing formulations to explore the mechanism of action,efficacy evaluation and safety evaluation.This paper presents insights and operational steps for the application of network pharmacology in the above aspects,with the aim of providing new scientific and technological support for the development of cosmetics.

关 键 词：网络药理学 研究进展 化妆品 应用展望 

分 类 号：TQ658[化学工程—精细化工]