合肥市成年男性血清25(OH)D_(3)水平与酒精性脂肪肝病的相关性  

Correlation between serum 25(OH)D_(3) levels and alcoholic fatty liver disease in adult males in Hefei

作　　者：王晓宇 王惠惠 曾藜 龚渭轶 杨冰冰[2] 徐德祥[3] 胡纯秋[1] WANG Xiaoyu;WANG Huihui;ZENG Li;GONG Weiyi;YANG Bingbing;XU Dexiang;HU Chunqiu(School of Public Health,Department of Nutrition and Food Hygiene,Anhui Medical University,Hefei 230032,China;Gastroenterology Department of the Fourth Hospital of Anhui Medical University,Hefei 230032,China;School of Public Health,Department of Health Toxicology,Anhui Medical University,Hefei 230032,China)

机构地区：[1]安徽医科大学公共卫生学院营养与食品卫生学系,合肥230032 [2]安徽医科大学第四附属医院消化内科,合肥230032 [3]安徽医科大学公共卫生学院卫生毒理学系,合肥230032

出　　处：《中华疾病控制杂志》2023年第8期928-932,共5页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(81402676);安徽省高等学校科学研究项目(2022AH040094)。

摘　　要：目的探讨合肥市成年男性血清25-羟维生素D_(3)[25⁃hydroxy vitamin D_(3),25(OH)D_(3)]水平与酒精性脂肪肝病(alcohol fatty liver disease,AFLD)的相关性。方法按入选标准收集AFLD患者90例及健康对照90例。通过问卷收集研究对象一般情况,查阅电子病例并收集临床检查资料,采用放射免疫分析法检测血清25(OH)D_(3)水平,logistic回归模型分析血清25(OH)D_(3)水平与AFLD的相关性。结果Mann⁃Whitney U检验显示AFLD患者血清25(OH)D_(3)水平[49.15(39.08,71.09)]低于对照组[67.04(51.03,76.84)](Z=-4.088,P<0.001)。趋势性χ^(2)检验显示AFLD患病率随25(OH)D_(3)水平增加而降低(χ^(2)趋势=13.13,P<0.001)。Mann⁃Whitney U检验显示中重度AFLD组25(OH)D_(3)水平[38.46(30.22,42.41)]低于轻度AFLD组[52.70(42.41,73.13)],且差异有统计学意义(Z=-3.172,P=0.001)。Logistic回归分析模型显示在调整混杂因素后,相对于血清25(OH)D_(3)缺乏的男性,血清25(OH)D_(3)不足和充足男性的AFLD发生风险降低(OR=0.085、OR=0.827)。结论血清25(OH)D_(3)水平与AFLD发生风险及严重程度有关。Objective To explore the correlation between 25⁃hydroxy vitamin D_(3)[25(OH)D_(3)]level and alcoholic fatty liver disease(AFLD)of adult males in Hefei.Methods A total of 90 patients with AFLD and 90 healthy controls were collected according to the inclusion criteria.General information of study subjects were collected through questionnaires,electronic medical records were consulted and clinical examination data were collected.Serum 25(OH)D_(3) levels were detected by radioimmunoassay.The correlation between serum 25(OH)D_(3) levels and AFLD was analyzed by logistic regression model.Results Mann⁃Whitney U test showed that serum 25(OH)D_(3)[49.15(39.08,71.09)]in patients with AFLD were significantly lower than the control group[67.04(51.03,76.84)](Z=-4.088,P<0.001).Trendingχ^(2)test showed that the prevalence of AFLD increases with increasing 25(OH)D_(3) levels(χ^(2)trend=13.13,P<0.001).Mann⁃Whitney U test showed that the level of 25(OH)D_(3)[38.46(30.22,42.41)]in the moderate to severe AFLD group was significantly lower than that in the mild AFLD group[52.70(42.41,73.13)],and the difference was statistically significant(Z=-3.172,P=0.001).The logistic regression analysis showed that men with insufficient and adequate serum 25(OH)D_(3) had a reduced risk of AFLD when compared with men with serum 25(OH)D_(3) deficiency after adjusting for confounders(OR=0.085,OR=0.827).Conclusion The serum 25(OH)D_(3) level of adult men in Hefei was associated with the risk and severity of AFLD.

关 键 词：25(OH)D_(3)水平 酒精性脂肪肝病 成年男性 相关性 

分 类 号：R181[医药卫生—流行病学] R589[医药卫生—公共卫生与预防医学]