2015―2021年陕西省丙型病毒性肝炎流行特征和空间聚集性  

Epidemiological characteristics and spatial clustering analysis of hepatitis C in Shaanxi Province from 2015 to 2021

作　　者：宁少奇 刘晨越 胡丹妮 曹磊[1] 陈飒[1] 张路钱 年云鹏 张义[1] NING Shaoqi;LIU Chenyue;HU Danni;CAO Lei;CHEN Sa;ZHANG Luqian;NIAN Yunpeng;ZHANG Yi(Shaanxi Provincial Centre for Disease Control and Prevention Institute for Infectious Disease Prevention and Control,Xi′an 710054 China;,Xi′an Jiaotong University Health Science Center,Xi′an 710061 China;The First Affiliated Hospital of Xi′an Medical University Imaging Department,Xi′an 710054 China)

机构地区：[1]陕西省疾病预防控制中心传染病预防控制所,西安710054 [2]西安交通大学医学部,西安710061 [3]西安医学院第一附属医院影像科,西安710054

出　　处：《中华疾病控制杂志》2023年第8期983-988,共6页Chinese Journal of Disease Control & Prevention

基　　金：渭南市华州区丙型肝炎的危险因素及防制策略研究(2018ZDXM-SF-058);陕西省卫生应急作业平台建设项目(2020PT-030)。

摘　　要：目的对陕西省丙型病毒性肝炎(丙肝)的流行特征和空间聚集性进行分析,为重点区域及重点人群的防控提供科学依据。方法收集2015―2021年陕西省丙肝报告病例资料,对数据进行查重。采用描述性流行病学分析其三间分布特征,使用R4.0.4和GeoDa1.6软件进行全局和局部空间聚集性分析。结果2015―2021年陕西省报告丙肝发病率呈总体下降趋势(χ^(2)_(趋势)=590.919,P<0.001)。男女性别比为1.06∶1,40~<70岁年龄组报告病例数较多,职业以农民、家务及待业、离退休人员为主。全局自相关分析发现2016、2017、2018、2019、2021年Moran′s I系数均为正值(均P<0.05);热点分析发现,丙肝发病高聚集区域2016年(12个)、2017年(14个)、2018年(12个)、2019年(9个)、2021年(8个)主要集中于关中的中部和东部地区。结论陕西省丙肝发病存在人群异质性和地区聚集性,应加强重点人群和地区的疫情监测、健康教育,提高整体防护意识,提供医疗援助并尽早控制传染源。Objective To analyze the epidemic characteristics and spatial aggregation of the hepatitis C virus in Shaanxi Province,thereby offering scientific evidence for the prevention and control.Methods We collected data on Hepatitis C virus infection cases in Shaanxi Province from 2015 to 2021,eliminating duplicate cases.The distribution characteristics were analyzed by descriptive epidemiological study,R 4.0.4 and GeoDa 1.6 software was used to conduct spatial statistical analyses.Results The reported incidence in Shaanxi Province from 2015 to 2021 showed an overall downward trend(χ^(2)=590.919,P<0.001).The male⁃to⁃female ratio was 1.06∶1,with the majority of reported cases found in the 40-<70 age group.The primary occupations of these infected were farmers,housework,unemployed individuals and retirees.Global autocorrelation analysis found positive Moran′s I coefficients in 2016,2017,2018,2019,and 2021(all P<0.05).Hot Spot analysis identified high concentration areas of hepatitis C virus in 2016(12),2017(14),2018(12),2019(9),2021(8),which were mainly concentrated in the central and eastern regions of Guanzhong.Conclusions The incidence of Hepatitis C virus in Shaanxi Province displays distinct population characteristics and regional clustering.Therefore,we should enhance epidemic surveillance and health education among high⁃risk populations and key regions,improve overall protective awareness,and provide medical assistance to control the infection source as early as possible.

关 键 词：丙型病毒性肝炎 流行特征 空间聚集性分析 

分 类 号：R51[医药卫生—内科学] R181[医药卫生—临床医学]