HBC患者RDW、PA、WPR的水平变化和临床意义  

Changes of RDW,PA and WPR in Patients with HBC and Their Clinical Significance

作　　者：刘新矿 陈紫君 LIU Xinkuang;CHEN Zijun(The First Affiliated Hospital of Anhui University of Science and Technology,Huainan,Anhui 232007,China)

机构地区：[1]安徽理工大学第一附属医院,安徽淮南232007

出　　处：《安徽理工大学学报（自然科学版）》2023年第2期98-102,共5页Journal of Anhui University of Science and Technology:Natural Science

基　　金：安徽省重点研究与开发计划资助项目(202004J07020053)。

摘　　要：目的探讨乙肝肝硬化(HBC)患者红细胞分布宽度(RDW)、前白蛋白(PA)、白细胞(WBC)、血小板(PLT)、白细胞比血小板(WPR)的水平变化,分析其临床意义。方法遴选2020年1月到2022年10月就诊于安徽理工大学第一附属医院的HBC患者120例作为研究组,根据Child-pugh分级将研究组分为3组:A组50例、B组44例、C组26例。将同时段120名健康检查者作为对照组。检测并分析患者RDW、PLT、PA、WBC、WPR水平变化,运用受试者工作特征曲线(ROC)评估其诊断价值。结果RDW、PA、PLT、PA、WBC、WPR在对照组和研究组之间存在明显差异(P<0.01)。RDW、PA在Child-pugh分级分组方面差异显著(P<0.01)。RDW与Child-pugh分级显著正相关(P<0.01),WBC与Child-pugh分级正相关(P<0.05),PA与Child-pugh分级显著负相关(P<0.01)。ROC曲线分析结果显示RDW、WPR对乙肝肝硬化的诊断均具有统计学意义(P<0.01),二者联合检测的特异性和敏感性分别为84.2%和98.3%,AUC值为0.961,高于单个指标检测(P<0.01)。结论RDW、WBC、PA与Child-pugh分级具有相关性,可以作为HBC患者病情轻重程度的参考指标。RDW、WPR可以作为诊断HBC的临床指标。Objective To investigate the changes of red blood cell distribution width(RDW)、prealbumin(PA)、white blood cell(WBC)、platelet(PLT)and white blood cell ratio platelet(WPR)in patients with hepatitis B cirrhosis(HBC),and to analyze its clinical significance.Methods A total of 120 HBC patients admitted to the First Affiliated Hospital of Anhui University of Science and Technology from January 2020 to October 2022 were selected as the study group.According to Child-pugh classification,the study group was divided into three sub-groups:Group A(50 cases),group B(44 cases)and group C(26 cases).A total of 120 healthy subjects in the same period were used as the control group.RDW、PLT、PA、WBC and WPR were detected and analyzed,and the diagnostic value was evaluated by receiver operating characteristic curve(ROC).Results RDW、PA、PLT、PA、WBC and WPR were significantly different between the control group and the study group(P<0.01).RDW and PA were significantly different in Child-pugh classification(P<0.01).RDW was positively correlated with Child-pugh classification(P<0.01),WBC was positively correlated with Child-pugh classification(P<0.05),and PA was negatively correlated with Child-pugh classification(P<0.01).The ROC curve analysis results showed that RDW and WPR had statistical significance in the diagnosis of hepatitis B cirrhosis(P<0.01).The specificity and sensitivity of RDW and WPR combined detection were 84.2%and 98.3%respectively,and the AUC value was 0.961,which was higher than that of single index detection(P<0.01).Conclusion RDW、WBC and PA are correlated with Child-pugh grading,which can be used as reference indicators for the severity of HBC patients.RDW and WPR can be used as clinical indicators to diagnose HBC.

关 键 词：红细胞分布宽度 前白蛋白 白细胞比血小板 乙肝肝硬化 CHILD-PUGH分级 

分 类 号：R512.62[医药卫生—内科学]