脂滴表面蛋白perilipin家族在癌症中的研究进展  

Research Progress of Perilipin Family of Lipid Droplet SurfaceProteins in Cancer

作　　者：王群 孙雨欣 王海峰 WANG Qun;SUN Yuxin;WANG Haifeng(Dept.of Urology,The Second Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650106,China)

机构地区：[1]昆明医科大学第二附属医院泌尿外科,云南昆明650106

出　　处：《昆明医科大学学报》2023年第8期139-144,共6页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(82060464);云南省科技厅-昆明医科大学联合应用基础研究重点项目(202001AY070001-163)。

摘　　要：随着癌症逐渐的年轻化,以及日益增加的发生率与死亡率,人们越来越关注其的发生发展。不可忽视的是目前全球肥胖人口也处于上升趋势,越来越多的研究发现肥胖会导致患癌症的风险增加,脂质代谢异常更是癌症中突出的代谢改变之一。故而,关注脂质代谢在癌症中所扮演的角色显得格外重要。近些年,随着人们深入学习了解脂质代谢,发现了脂滴表面蛋白Perilipin家族,其功能不仅仅是脂滴的结构蛋白,其与癌细胞的增殖、侵袭及转移等都密切相关。因此,Perilipin家族可能成为癌症治疗的一个潜在的有希望的靶点。主要综述了Perilipin家族各成员最新发现的在癌症中的作用及相关机制,这些研究将加深对Perilipin家族在癌症进展过程中的功能的认识,为更好预防控制癌症提供新的切入点。With cancer becoming increasingly prevalent and affecting younger populations,there is growing concern about its development and progression.It is worth noting that the global population of obese individuals is also on the rise,and numerous studies have found that obesity increases the risk of developing cancer.Abnormal lipid metabolism is one of the prominent metabolic changes in cancer development.Therefore,it is crucial to pay attention to the role of lipid metabolism in cancer.In recent years,as researchers have delved deeper into the study of lipid metabolism,the perilipin family of lipid droplet surface proteins has been discovered.These proteins not only serve as structural proteins for lipid droplets,but they are also closely associated with cancer cell proliferation,invasion,and metastasis.Therefore,the perilipin family may represent a potential and promising target for cancer treatment.This review primarily focuses on the latest findings regarding the roles and mechanisms of the perilipin family members in cancer.These studies will deepen our understanding of the functions of the perilipin family in the progression of cancer and provide new insights for better cancer prevention and control.

关 键 词：癌症 脂滴 脂滴表面蛋白Perilipin家族 脂质代谢 

分 类 号：R34[医药卫生—基础医学] R73