COPD患者外周血中性粒细胞与淋巴细胞比值与免疫功能的相关性  

Correlation between neutrophil to lymphocyte ratio in peripheral blood and immune function in COPD patients

作　　者：戴诗敏[1] 向永红[1] 庞宗东 潘海燕 苏盈 郑菲 Dai Shimin;Xiang Yonghong;Pang Zongdong;Pan Haiyan;Su Ying;Zheng Fei(Department of Respiratory and Critical Care Medicine,Guangxi Hospital for Nationalities,Nanning,Guangxi 530001,China)

机构地区：[1]广西壮族自治区民族医院呼吸与危重症医学科,广西南宁530001

出　　处：《现代临床医学》2023年第5期324-327,共4页Journal of Modern Clinical Medicine

基　　金：崇左市科技计划项目(崇科攻2020020)。

摘　　要：目的:探讨慢性阻塞性肺疾病(COPD)患者外周血中性粒细胞和淋巴细胞比值(NLR)与免疫功能的关系。方法:选取我院2020年10月至2021年11月收治的110例COPD患者,根据诊断标准分为急性加重组(70例)和稳定组(40例),以同期100例健康体检者为对照组。检测各组NLR、C⁃反应蛋白(CRP)、T细胞亚群、免疫球蛋白,比较3组间NLR及免疫功能指标的差异,分析NLR与免疫功能指标的相关性。结果:急性加重组NLR、CRP及CD8^(+)高于稳定组和对照组,而CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、IgA、IgG、IgM低于稳定组和对照组(P<0.05)。稳定组NLR、CRP及CD8^(+)高于对照组,而CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、IgA、IgG、IgM低于对照组(P<0.05)。COPD患者的NLR与CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)呈负相关,与CD8^(+)呈正相关(P<0.05)。结论:NLR不仅可作为反映COPD患者炎症状态及病情严重程度的指标,还与外周血T细胞亚群存在相关性,可反映COPD患者T细胞免疫功能。Objective:To explore the correlation between neutrophil to lymphocyte ratio(NLR)in peripheral blood and immune function in patients with chronic obstructive pulmonary disease(COPD).Methods:110 COPD patients admitted to our hospital from October 2020 to November 2021 were selected and divided into acute exacerbation group(70 cases)and stable group(40 cases)based on diagnostic criteria.100 healthy individuals during the same period were selected as control group.The NLR,C⁃reactive protein(CRP),T cell subsets,and immunoglobulins were detected in each group.The differences in NLR and immune function indicators among the three groups were compared,and the correlations between NLR and immune function indicators were analyzed.Results:In the acute exacerbation group,the NLR,CRP,and CD8^(+)were higher than those in the stable and control groups,while CD3^(+),CD4^(+),CD4^(+)/CD8^(+),IgA,IgG,and IgM were lower than those in the stable and control groups(P<0.05).In the stable group,the NLR,CRP,and CD8^(+)were higher than those in the control group,while CD3^(+),CD4^(+),CD4^(+)/CD8^(+),IgA,IgG,and IgM were lower than those in the control group(P<0.05).The NLR of COPD patients was negatively correlated with CD3^(+),CD4^(+),CD4^(+)/CD8^(+),and positively correlated with CD8^(+)(P<0.05).Conclusion:NLR can not only serve as an indicator to reflect the status of inflammation and the severity of disease in COPD patients,but also has a correlation with T cell subsets in peripheral blood,which can reflect the immune function of T cell in COPD patients.

关 键 词：慢性阻塞性肺疾病 中性粒细胞与淋巴细胞比值 免疫功能 炎症 

分 类 号：R563[医药卫生—呼吸系统]