新生儿发生胃肠外营养相关性胆汁淤积的危险因素分析及干预策略  

Risk factors and intervention strategies for parenteral nutrition⁃associated cholestasis in newborns

作　　者：温清华 Wen Qinghua(Department of Neonatology,People's Hospital of Bao'an District,Shenzhen,Guangdong 518100,China)

机构地区：[1]深圳市宝安区人民医院新生儿科,广东深圳518100

出　　处：《现代临床医学》2023年第5期331-334,共4页Journal of Modern Clinical Medicine

摘　　要：目的:对新生儿发生胃肠外营养相关性胆汁淤积(PNAC)的危险因素进行分析,并制定针对性干预措施。方法:回顾性选取2019年12月至2021年12月我院收治的201例接受胃肠外营养(PN)的新生儿,根据是否发生PNAC分为PNAC组(24例)和非PNAC组(177例)。将两组新生儿的相关资料进行单因素及多因素分析,筛选新生儿接受PN后发生PNAC的独立危险因素。结果:logistic回归分析显示,新生儿感染、PN热卡累积量高、脂肪乳累积用量高、氨基酸累积用量高、PN持续时间长、禁食时间长、PN 14 d肠内热卡值低均为新生儿接受PN后发生PNAC的危险因素(P<0.05)。结论:新生儿接受PN后发生PNAC的危险因素较多,应采取相应的干预措施,以减少PNAC的发生。Objective:To analyze the risk factors for parenteral nutrition⁃associated cholestasis(PNAC)in newborns so as to develop targeted intervention measures.Methods:201 newborns who received parenteral nutrition(PN)in our hospital were retrospectively selected from December 2019 to December 2021.They were divided into PNAC group(24 cases)and non⁃PNAC group(177 cases)based on whether PNAC occurred.Univariate and multivariate analyses were performed on the relevant data of newborns in two groups,and independent risk factors for PNAC after PN were screened.Results:Logistic regression analysis showed that neonatal infection,high PN calorie accumulation,high accumulated usage of fat emulsion accumulation,high accumulated usage of amino acid,long duration of PN,long fasting time,and low intestinal calorie value on day 14 were all risk factors for PNAC after PN(P<0.05).Conclusion:There are many risk factors for PNAC in newborns after PN,and corresponding intervention measures should be taken to reduce the occurrence of PNAC.

关 键 词：新生儿 胃肠外营养 胆汁淤积 危险因素 

分 类 号：R722.1[医药卫生—儿科]