天然复合抗菌材料Car-CTAB/MMT的制备、表征及抑菌活性研究  

Study on the preparation,characterization and antibacterial activity of natural composite antibacterial material Car-CTAB/MMT

作　　者：郭佳彦 何秋蓉 麻晓霞[1] 高灵娟 GUO Jiayan;HE Qiurong;MA Xiaoxia;GAO Lingjuan(State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering,College of Chemistry and Chemical Engineering,Ningxia University,Yinchuan Ningxia 750021,China)

机构地区：[1]宁夏大学化学化工学院,省部共建煤炭高效利用与绿色化工国家重点实验室,宁夏银川750021

出　　处：《石油化工应用》2023年第8期87-91,113,共6页Petrochemical Industry Application

基　　金：宁夏自然科学基金项目,项目编号:2023AAC03078。

摘　　要：基于天然抗菌剂香芹酚(Car)优良的抗菌活性,以十六烷基三甲基溴化铵(CTAB)改性蒙脱石为载体,制备了一种新型复合抗菌材料Car-CTAB/MMT,并对其表面结构、性质和抑菌活性进行了表征。结果表明,Car-CTAB/MMT比游离态香芹酚对大肠杆菌有更好的抑菌活性,其最小抑菌浓度(MIC)和最小杀菌浓度(MBC)分别为62.5μg/mL、125.0μg/mL。该抗菌材料破坏了细菌细胞形态,损坏了细胞壁结构,细胞通过性和细胞膜渗透性均增加,细胞内蛋白质和核酸发生泄漏,从而达到抗菌的效果。A new composite antibacterial material Car-CTAB/MMT was prepared by the excellent antibacterial activity of carvacrol(Car)and montmorillonite modified by cetyltrimethylammonium bromide(CTAB).The surface structure,properties and antibacterial activity of Car-CTAB/MMT were characterized.The results showed that Car-CTAB/MMT had better antibacterial activity against escherichia coli than free carvacrol.The MIC and MBC of Car-CTAB/MMT were 62.5μg/mL and 125.0μg/mL,respectively.The antibacterial material destroyed the bacterial cell morphology and damaged the structure of cell wall,which increases the cell permeability and cell membrane permeability.The leakage of intracellular protein and nucleic acid lead to achieve the antibacterial effect.

关 键 词：香芹酚 蒙脱石 抗菌材料 抑菌活性 

分 类 号：TB34[一般工业技术—材料科学与工程]