自噬与间充质干细胞治疗神经退行性病的相互作用  

Interaction between autophagy and mesenchymal stem cells in treatment of neurodegenerative diseases

作　　者：肖怡 卢硕 葛丽特 卢明[1] Xiao Yi;Lu Shuo;Ge Lite;Lu Ming(Second Affiliated Hospital of Hunan Normal University(921 Hospital),Hunan Provincial Key Laboratory of Neurorestoratology,Changsha 410003,Hunan Province,China;Department of Neurology,Second Xiangya Hospital,Central South University,Changsha 410003,Hunan Province,China)

机构地区：[1]湖南师范大学第二附属医院(第921医院),神经修复学湖南省重点实验室,湖南省长沙市410003 [2]中南大学湘雅二医院神经内科,湖南省长沙市410003

出　　处：《中国组织工程研究》2024年第19期3111-3116,共6页Chinese Journal of Tissue Engineering Research

基　　金：湖南省重点研发计划项目(2020SK2102),项目负责人:卢明;湖南省教育厅研究生科研创新项目(CX20220528),项目负责人:肖怡。

摘　　要：背景:神经元的自噬功能紊乱和异常蛋白质聚集是神经退行性疾病的主要病理改变,间充质干细胞与自噬的联系及其相互作用代表一种治疗神经退行性疾病可能的机制。目的:围绕自噬与间充质干细胞治疗神经退行性疾病及其相互作用的研究进展进行综述,旨在为治疗神经退行性疾病提供理论依据和新思路。方法:在PubMed和中国知网数据库以“autophagy,neurodegenerative diseases,mesenchymal stem cells,Parkinson’s disease,Alzheimer’s disease”为英文检索词,以“自噬,神经退行性疾病,间充质干细胞,帕金森病,阿尔茨海默病”为中文检索词,检索相关文献,最终纳入59篇文献进行综述。结果与结论:①自噬平衡有益于维持中枢神经系统内外环境的稳定性以及控制神经退行性疾病的病程进展;②自噬作为一种维持细胞更新和平衡状态的动态循环机制,可影响间充质干细胞的迁移、存活、分化、抗凋亡和免疫调控等生物学功能,同时优化其对疾病的治疗疗效;③间充质干细胞是一类重要的神经保护剂,可通过调节细胞自噬水平高低,以此减轻神经退行性疾病的病理学特征并改善其功能障碍,这可能与分解代谢过程中特定的细胞条件和激活水平有关。BACKGROUND:Neuronal autophagy disorder and abnormal protein aggregation are the main pathological changes of neurodegenerative diseases.The relationship and interaction between mesenchymal stem cells and autophagy represent a possible mechanism for the treatment of neurodegenerative diseases.OBJECTIVE:To review the research progress of autophagy and mesenchymal stem cells in the treatment of neurodegenerative diseases and their interaction in order to provide a theoretical basis and new ideas for the treatment of neurodegenerative diseases.METHODS:PubMed and CNKI databases were searched for relevant articles using“autophagy,neurodegenerative diseases,mesenchymal stem cells,Parkinson’s disease,Alzheimer’s disease”as the search terms in Chinese and English.Totally,59 articles were included for review.RESULTS AND CONCLUSION:(1)Autophagy homeostasis is beneficial for maintaining the stability of the internal and external environment of the central nervous system and for controlling the progression of neurodegenerative disease.(2)As a dynamic circulation mechanism to maintain cell renewal and equilibrium,autophagy can affect the biological functions of mesenchymal stem cells such as migration,survival,differentiation,anti-apoptosis and immune regulation,and optimize their therapeutic efficacy for diseases.(3)Mesenchymal stem cells are an important class of neuroprotective agents that can alleviate pathological features and improve dysfunction in neurodegenerative diseases by regulating the level of cellular autophagy,which may be related to specific cellular conditions and activation levels in catabolic processes.

关 键 词：自噬 神经退行性疾病 间充质干细胞 帕金森病 阿尔茨海默病 

分 类 号：R472[医药卫生—护理学] R318[医药卫生—临床医学] R741.02