疏肝益阳胶囊干预下勃起功能障碍和早泄患者性功能相关量表指标与不良反应的Meta分析  

Meta-analysis of sexual function related scale and adverse reaction rate of erectile dysfunction and premature ejaculation patients under Shugan Yiyang Capsule intervention

作　　者：李鲁豫 琚保军[2] 李霄[2] 张永涛 马苗苗 姚均超 LI Luyu;JU Baojun;LI Xiao;ZHANG Yongtao;MA Miaomiao;YAO Junchao(The First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou450000,Henan,Chin;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou450000,Henan,Chin)

机构地区：[1]河南中医药大学第一临床医学院,郑州450000 [2]河南中医药大学第一附属医院,郑州450000

出　　处：《中国性科学》2023年第9期119-124,共6页Chinese Journal of Human Sexuality

基　　金：河南省中医药科学研究专项课题(河南省中医管理局课题)(2018ZY2065)。

摘　　要：目的评价疏肝益阳胶囊干预下患者性功能相关量表指标的改善情况与不良反应率,为该药物的临床使用提供循证医学证据。方法计算机检索中国知网(CNKI)、万方数据库(Wanfang)、维普数据库(VIP)、SinoMed、PubMed等数据库获得相关文献,检索时限均从建库至2022年7月,采用RevMan 5.4软件进行Meta分析。结果共纳入15篇文献,1697例患者,Meta分析结果显示,疏肝益阳胶囊干预下患者国际勃起功能指数问卷表-5(IIEF-5)、中国早泄患者性功能评价表-5(CIPE-5)、患者性生活满意度(Q6)、配偶性生活满意度(Q7)、阴道内射精潜伏期(IELT)均有提高。IIEF-5:MD=2.77,95%CI为2.11~3.42,P<0.00001;CIPE-5:MD=3.83,95%CI为2.38~5.28,P<0.00001;Q6:MD=0.56,95%CI为0.35~0.77,P<0.00001;Q7:MD=0.57,95%CI为0.22~0.91,P=0.001;IELT:SMD=1.01,95%CI为0.50~1.52,P=0.0001;患者不良反应率明显降低:RR=0.52,95%CI为0.40~0.68,P<0.00001。结论疏肝益阳胶囊干预可明显改善患者勃起功能,延长射精时间,改善夫妻性生活,降低5型磷酸二酯酶抑制剂(PDE5i)和5-羟色胺重摄取抑制剂(SSRIs)产生的不良反应,改善服用SSRIs造成的性欲下降。Objective To evaluate the improvement of sexual function related scale and adverse reaction rate of patients under the intervention of Shugan Yiyang Capsule,so as to provide evidence-based medical evidence for the clinical use of this drug.Methods Relevant literatures were retrieved from China National Knowledge Infrastructure(CNKI),Wanfang,China Science and Technology Journal Database(VIP),SinoMed,PubMed and other databases.The retrieval time was from the establishment of the database to July 2022.RevMan 5.4 software was used for meta-analysis.Results A total of 15 literatures were included,involving 1,697 patients and the meta-analysis showed that the international index of erectile function-5(IIEF-5),Chinese index of premature ejaculation-5(CIPE-5),patient sexual satisfaction(Q6),couple sexual satisfaction(Q7),intra-vaginal ejaculation latency time(IELT)of patients with Shugan Yiyang Capsule intervention were all improved.IIEF-5:MD=2.77,95%CI(2.11-3.42),P0.000,01;CIPE-5:MD=3.83,95%CI(2.38-5.28),P0.000,01;Q6:MD=0.56,95%CI(0.35-0.77),P0.000,01;Q7:MD=0.57,95%CI(0.22-0.91),P=0.001;IELT:SMD=1.01,95%CI(0.50-1.52),P=0.000,1.The rate of adverse reactions was significantly decreased[RR=0.52,95%CI(0.40-0.68),P0.000,01].Conclusions Shugan Yiyang Capsule can significantly improve erectile function of patients,prolong ejaculation time,improve sexual life of couples,reduce adverse reactions caused by phosphodie-sterase type 5 inhibitor(PDE5i)and serotonin-selective reuptake inhibitors(SSRIs),and improve the decreased libido caused by taking SSRIs.

关 键 词：疏肝益阳胶囊 5型磷酸二酯酶抑制剂 5-羟色胺重摄取抑制剂 勃起功能障碍 早泄 

分 类 号：R277.5[医药卫生—中医学]