吲哚布芬联合氯吡格雷治疗对冠心病PCI术后患者心肌灌注、NT-proBNP及MACE的影响  

The Effect of Indobufen combined with Clopidogrel on myocardial Perfusion,NT-proBNP,and MACE in Patients with coronary Heart Disease after PCI

作　　者：陈永成[1] CHEN Yongcheng(Cardiac Intensive Care Unit,People's Hospital of Taikang County,Zhoukou Henan 461400,China)

机构地区：[1]太康县人民医院心脏重症监护室,河南周口461400

出　　处：《临床研究》2023年第10期53-56,共4页Clinical Research

摘　　要：目的分析冠心病(CHD)患者行经皮冠脉介入治疗(PCI)术后采用氯吡格雷联合吲哚布芬疗法对患者心肌灌注、氨基末端B型钠尿肽原(NT-proBNP)及主要心血管不良事件(MACE)的影响。方法选取太康县人民医院于2020年1月至2021年4月收治的84例CHD行PCI术后患者,按随机数字表法将其分为观察组与对照组两组,每组各42例。对照组患者使用氯吡格雷联合阿司匹林进行双联抗血小板治疗(DAPT),观察组使用氯吡格雷联合吲哚布芬DAPT。比较治疗前后两组凝血功能指标与两组心肌损伤标志物水平;分析术后6月内两组MACE发生率与治疗过程中两组药物不良反应发生率。结果与治疗前相比,治疗后两组凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)水平均显著升高,差异有统计学意义(P<0.05),两组NT-proBNP与与心肌肌钙蛋白Ⅰ(cTnⅠ)水平均明显下降,差异有统计学意义(P<0.05),观察组改善效果更加显著,差异有统计学意义(P<0.05);治疗后两组血小板计数较治疗前均显著下降,差异有统计学意义(P<0.05);观察组MACE发生率明显低于对照组,差异有统计学意义(P<0.05)。结论氯吡格雷联合吲哚布芬治疗CHD患者PCI术后,可有效改善患者凝血功能,减少心肌损伤,相较于氯吡格雷联合阿司匹林方案更有利于预防MACE发生,疗效性与安全性均属良好。Objective To analyze the effects of clopidogrel combined with indoprofen therapy on myocardial perfusion,N-terminal B-type natriuretic peptide(NT-proBNP),and major cardiovascular adverse events(MACE)in patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods A total of 84 patients with CHD who underwent PCI at the People's Hospital of Taikang County,Henan Province from January 2020 to April 2021 were selected and randomly divided into an observation group and a control group using a random number table method,with 42 patients in each group.The control group patients received dual antiplatelet therapy(DAPT)with clopidogrel combined with aspirin,while the observation group received DAPT with clopidogrel combined with indobufen.The levels of coagulation function indicators and myocardial injury markers between the two groups before and after treatment were compared;The incidence of MACE in both groups within 6 months after surgery and the incidence of adverse drug reactions during treatment was analyzed.Results Compared with before treatment,the levels of thrombin time(TT),activated partial thromboplastin time(APTT),and prothrombin time(PT)were significantly increased in both groups after treatment,with a statistically significant difference(P<0.05).The levels of NT-54 Clinical Research,Oct.2023,Vol.31 No.10 proBNP and cardiac troponinⅠ(cTnⅠ)were significantly decreased in both groups,with a statistically significant difference(P<0.05).The improvement effect in the observation group was more significant,with a statistically significant difference(P<0.05);After treatment,the platelet count of both groups significantly decreased compared to before treatment,with a statistically significant difference(P<0.05);The incidence of MACE in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of clopidogrel and indobufen in the treatment of CHD patients after PCI can effectively

关 键 词：经皮冠脉介入治疗 吲哚布芬 抗血小板 心肌灌注 主要不良心血管事件 

分 类 号：R541.4[医药卫生—心血管疾病]