尿酸转运体BCRP与GLUT9基因多态性与吡嗪酰胺致高尿酸血症的相关性研究  

Urate transporters BCRP,GLUT9 gene polymorphisms and pyrazinamide induced hyperuricemia

作　　者：蒲强红[1] 林茂 吴珊 袁术生 李凡敏 PU Qiang-Hong;LIN Mao;WU Shan(Department of Pharmacy,People’s hospital of Leshan,Leshan 614000,China;不详)

机构地区：[1]乐山市人民医院药学部 [2]乐山市人民医院感染性疾病科 [3]乐山市人民医院呼吸内科,四川乐山614000

出　　处：《中国处方药》2023年第9期13-16,共4页Journal of China Prescription Drug

基　　金：四川省卫生和计划生育委员会科研课题(17PJ560)。

摘　　要：目的评估尿酸转运体BCRP与GLUT9基因多态性与吡嗪酰胺致高尿酸血症的相关性。方法纳入2016年7月~2021年12月期间113例结核病病例,强化期选用HRZE方案,根据强化期血尿酸水平分为高尿酸血症与正常血尿酸两组,并检测尿酸转运体BCRP与GLUT9基因多态性。结果高尿酸血症组与正常血尿酸组间BCRP基因多态性rs2231142的基因型差异无统计学意义(P>0.05);GLUT9基因多态性rs16890979、rs6449213与rs7442295的基因型差异无统计学意义(P>0.05)。结论尿酸转运体BCRP与GLUT9基因多态性可能不与吡嗪酰胺致高尿酸血症相关。Objective To assess the correlation of urate transporters BCRP,GLUT9 gene polymorphisms and pyrazinamide-induced hyperuricemia in patients with tuberculosis.Methods Patients were enrolled during July 2016 to December 2021,HRZE regimen[isoniazid(H),rifampin(R),pyrazinamide(Z)and ethambutol(E)]were administrated in intensive period.Patients were devided into hyperuricemia and normouricemia groups according to serum uric acid in intensive period,and urate transporters BCRP and GLUT9 gene polymorphisms were determinded using Sanger methods.Results No significant difference existed in BCRP gene polymorphisms rs2231142 between hyperuricemia and normouricemia(P>0.05).Moreover,similar trends were found in GLUT9 gene polymorphisms rs16890979,rs644921 and rs7442295(P<0.05).Conclusion Urate transporters BCRP and GLUT9 gene polymorphisms possibly don't correlate with pyrazinamide induced hyperuricemia.

关 键 词：吡嗪酰胺 高尿酸血症 尿酸转运体 基因多态性 结核病 

分 类 号：R969[医药卫生—药理学]