米诺环素联合甲硝唑对牙周炎患者炎症反应及牙周健康的影响  

Effect of minocycline and metronidazole on inflammatory response and periodontal health in patients with periodontitis

作　　者：刘文英 车德平 Liu Wenyin;Che Depin(Fuzhou Maternal and Child Health Hospital,Jiangxi 344100;Fuzhou First People's Hospital,Jiangxi 344100)

机构地区：[1]江西省抚州市妇幼保健院,江西344100 [2]江西省抚州市第一人民医院,江西344100

出　　处：《天津药学》2023年第4期19-22,共4页Tianjin Pharmacy

摘　　要：目的:探讨米诺环素联合甲硝唑在牙周炎患者中的治疗效果。方法:选取2021年5月—2022年7月本院收治的68例牙周炎患者,按随机数字表法分两组,各34例。所有患者均进行根面平整、龈下刮治等基础治疗,做好口腔卫生指导等工作。对照组采取甲硝唑治疗:以牙周袋深度为准,用剪刀将甲硝唑药膜分成小段,用镊子将其置于牙周袋内,2次/周。在对照组基础上,观察组将盐酸米诺环素软膏注入牙周袋中,直至充满,1次/周。两组患者均治疗4周后评估疗效。比较两组临床疗效、炎症反应、牙周健康指标、生活质量及安全性。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前两组炎症反应、牙周健康指标和生活质量比较,差异无统计学意义(P>0.05);治疗后两组白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白介素-1β(IL-1β)、牙周袋深度(PD)、牙龈指数(GI)、牙菌斑指数(PLI)、牙周附着水平(PAL)和龈沟出血指数(SBI)低于治疗前,且观察组低于对照组(P<0.05);两组世界卫生组织生存质量测定量表(WHOQOL-BREF)量表中的生理维度、心理维度、社会维度、环境维度评分高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。两组治疗期间均无严重不良反应。结论:米诺环素联合甲硝唑能增强牙周炎治疗效果,减轻炎症反应,并改善牙周健康水平与生活质量,安全可靠。Objective:To investigate the therapeutic effect of minocycline combined with metronidazole in patients with periodontitis.Methods:According to the random number table method,68 periodontitis patients admitted to our hospital from May 2021 to July 2022 were selected and divided into two groups,with 34 cases in each group.All patients received basic treatment,such as root surface leveling,subgingival scaling,and oral health guidance.The control group was treated with metronidazole:depending on the periodontal pocket depth,the metronidazole film was divided into small segments with scissors and placed in the periodontal pocket with tweezers twice a week.Based on the control group,the observation group injected minocycline hydrochloride ointment into the periodontal pocket until complete once a week.The efficacy was evaluated after four weeks of treatment in both groups.The clinical efficacy,inflammatory response,periodontal health indexes,quality of life,and safety of the two groups were compared.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in inflammatory response,periodontal health index,and quality of life between the two groups before treatment(P>0.05).After treatment,interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),hypersensitive C-reactive protein(hs-CRP),interleukin-1β(IL-1β),periodontal pocket depth(PD),gingival index(GI),plaque index(PLI),periodontal attachment level(PAL),and gingival creval bleeding index(SBI)were lower than those before treatment,and the observation group was lower than the control group(P<0.05).The physiological,psychological,social,and environmental dimensions in the World Health Organization Quality Scale(WHOQOL-BREF)scale were higher than those before treatment,and the observation group was significantly higher than the control group(P<0.05).There were no serious adverse effects during the treatment in both groups.Conclusion:Minocycl

关 键 词：牙周炎 米诺环素 甲硝唑 临床疗效 炎症反应 牙周健康 

分 类 号：R988.2[医药卫生—药品]