盐酸米诺环素软膏联合替硝唑治疗慢性牙周炎患者临床效果研究  

Clinical effect of minocycline hydrochloride ointment combined with tinidazole in the treatment of chronic periodontitis

作　　者：刘超星 Liu Chaoxing(Henan Xuchang Traditional Chinese Medicine Hospital,Henan 461000)

机构地区：[1]河南省许昌中医院,河南461000

出　　处：《天津药学》2023年第4期47-50,共4页Tianjin Pharmacy

摘　　要：目的:探讨盐酸米诺环素软膏联合替硝唑对慢性牙周炎患者口腔健康相关指标及炎症因子的影响。方法:选取本院2019年3月—2022年5月收治的慢性牙周炎患者88例,按照随机数字表法分对照组(n=44)与观察组(n=44)。所有患者均给予龈上洁治,对照组盐酸米诺环素软膏注入牙周袋底部治疗,1次/周;观察组给予盐酸米诺环素软膏联合替硝唑治疗,盐酸米诺环素软膏用法用量同对照组,替硝唑口服,2.0 g/次,1次/d,4周为1个疗程。比较两组临床疗效、口腔健康相关指标[菌斑指数(PLI)、牙龈沟出血指数(SBI)、牙周袋深度(PPD)]、炎症因子[白介素-6(IL-6)、转化生长因子β(TGF-β)、基质金属蛋白酶-8(MMP-8)]及并发症发生情况。结果:观察组治疗总有效率为93.18%,高于对照组的75.00%,有统计学差异(P<0.05)。治疗前两组PLI、SBI、PPD、IL-6、TGF-β和MMP-8水平比较,差异无统计学意义(P>0.05);治疗后两组PLI、SBI、PPD、IL-6和MMP-8均较治疗前下降,且观察组低于对照组,两组TGF-β较治疗前升高,且观察组高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,无统计学差异(P>0.05)。结论:盐酸米诺环素软膏联合替硝唑治疗慢性牙周炎效果更佳,可有效改善患者口腔健康,减轻炎症反应,安全可靠。Objective:To investigate the effects of minocycline hydrochloride ointment combined with tinidazole on oral health-related indicators and inflammatory factors in patients with chronic periodontitis.Methods:A total of 88 patients with chronic periodontitis admitted to our hospital from March 2019 to May 2022 were selected and randomly divided into the control group(n=44)and the observation group(n=44).All patients were treated with supragingival scaling.In the control group,minocycline hydrochloride ointment was injected into the bottom of the periodontal pocket for treatment once a week.The observation group was treated with minocycline hydrochloride ointment combined with tinidazole.The dosage of minocycline hydrochloride ointment was the same as that of the control group.Tinidazole was taken orally,2.0 g/time,once a day,and four weeks was a course of treatment.The clinical efficacy,oral health-related indexes[plaque index(PLI),gingival groove bleeding index(SBI),periodontal pocket depth(PPD)],inflammatory factors[interleukin-6(IL-6),transforming growth factorβ(TGF-β),matrix metalloproteinase-8(MMP-8)],and complications were compared between the two groups.Results:The total effective rate of the observation group was 93.18%,which was higher than that of the control group(75.00%,P<0.05).Before treatment,there was no significant difference in the PLI,SBI,PPD,IL-6,TGF-β,and MMP-8 levels between the two groups(P>0.05).After treatment,PLI,SBI,PPD,IL-6,and MMP-8 in both groups decreased compared to before treatment,and the observation group was lower than the control group.TGF-βlevels in both groups were increased compared with before treatment,and the observation group was significantly higher than the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Minocycline hydrochloride ointment combined with tinidazole is more effective in treating chronic periodontitis,which can effectively improve patients'oral health,reduce inflamma

关 键 词：慢性牙周炎 盐酸米诺环素软膏 替硝唑 临床疗效 口腔健康 炎症因子 

分 类 号：R988.2[医药卫生—药品]