岳阳市某院儿童急性呼吸道人偏肺病毒感染情况及基因特征分析  

Infection status and genetic characteristics of human metapneumovirus in children with acute respiratory tract infection in Yueyang City

作　　者：彭芬[1] 杨毅[1] 余飞跃[1] 姜习新 PENG Fen;YANG Yi;YU Feiyue;JIANG Xixin(Yueyang Hospital Affiliated to Hunan Normal University/Yueyang Municipal People’s Hospital,Yueyang,Hunan 414000,China)

机构地区：[1]湖南师范大学附属岳阳医院/岳阳市人民医院,湖南岳阳414000

出　　处：《实用预防医学》2023年第8期936-939,共4页Practical Preventive Medicine

摘　　要：目的调查岳阳市某三级甲等医院儿童急性呼吸道人偏肺病毒(human metapneumovirus,HMPV)感染状况及基因分型。方法对2019年7月—2020年6月该院因急性呼吸道感染(acute respiratory tract infections,ARTI)住院的14岁以下儿童患者,收集临床资料,采集鼻咽拭子标本。采用实时聚合酶链反应检测HMPV。对HMPV阳性样本进行M和F基因分型。分析ARTI儿童患者中HMPV感染特点及基因分型特征。结果3175份ARTI患儿鼻咽拭子标本中共检出60例HMPV阳性,阳性检出率为1.9%。HMPV感染患儿年龄23 d~8岁。1岁以下婴幼儿占比30.0%(18/60)。季节分布中以夏季(57.7%)和秋季(36.7%)为主,在春季未检出HMPV感染。60例HMPV感染患儿中,临床诊断主要为支气管炎(65.0%,39/60)和肺炎(26.7%,16/60),临床表现主要为发热(71.7%,43/60)和咳嗽(71.7%,43/60)。HMPV感染者中,HMPV A2b基因型占比为53.3%。结论HMPV感染好发于1岁以下婴幼儿,监测时间段内流行高峰发生在夏秋两季,支气管炎是HMPV患者的主要诊断。主要流行株为A2b型。Objective To investigate the infection status and genotyping of human metapneumovirus(HMPV)in hospitalized children with acute respiratory tract infection(ARTI)in a grade-A tertiary hospital in Yueyang City.Methods Clinical data and nasopharyngeal swabs were collected from children under 14 years of age who were hospitalized with ARTI in the above-mentioned hospital from July 2019 to June 2020.HMPV was detected by real-time polymerase chain reaction.The HMPV-positive samples were genotyped for M and F.The infection characteristics and genotyping features of HMPV in children with ARTI were analyzed.Results A total of 60 children patients with ARTI were positive for HMPV in 3,175 nasopharyngeal swabs detected,with a positive detection rate of 1.9%.The patients with HMPV infection ranged in age from 23 days to 8 years.The proportion of infants under 1 year old was 30.0%(18/60).Summer(57.7%)and autumn(36.7%)were predominant in the seasonal distribution,and no HMPV infection was detected in spring.Among the 60 children with HMPV infection,the main clinical diagnoses were bronchitis(65.0%,39/60)and pneumonia(26.7%,16/60),and the main clinical manifestations were fever(71.7%,43/60)and cough(71.7%,43/60).In the patients infected with HMPV,the HMPV A2b genotype accounted for 53.3%.Conclusion HMPV infection was most common in infants under 1 year old.The prevalence peak occurred in summer and autumn during the monitoring period.Bronchitis was the main diagnosis of the HMPV patients.The main prevalent strain was A2b type.

关 键 词：急性呼吸道感染 人偏肺病毒 儿童患者 临床特征 基因分型 

分 类 号：R725.6[医药卫生—儿科]