血清VAP-1、VCAM-1在甲状腺癌患者中的变化及意义  

Changes and significance of serum VAP-1 and VCAM-1 in patients with thyroid cancer

作　　者：张燕妮 胡玉海[1] ZHANG Yanni;HU Yuhai(Department of Clinical Laboratory,Wuhan Municipal Hankou Hospital,Wuhan,Hubei 430013,China)

机构地区：[1]湖北省武汉市汉口医院检验科,湖北武汉430013

出　　处：《检验医学与临床》2023年第18期2715-2719,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨血清血管黏附蛋白-1(VAP-1)、血管细胞黏附分子-1(VCAM-1)在甲状腺癌患者中的变化及意义。方法选取2020年7月至2022年5月该院收治的甲状腺癌患者57例作为甲状腺癌组,另选取同期确诊的甲状腺腺瘤患者47例作为甲状腺腺瘤组,同期体检健康者30例作为健康对照组。采用酶联免疫吸附试验检测各组血清VAP-1和VCAM-1水平,分析不同临床病理参数的甲状腺癌患者血清VAP-1和VCAM-1水平差异,绘制受试者工作特征(ROC)曲线分析血清VAP-1和VCAM-1诊断甲状腺癌的效能。结果甲状腺癌组术前血清中VAP-1水平显著低于甲状腺腺瘤组和健康对照组(P<0.05),而血清VCAM-1水平显著高于甲状腺腺瘤组和健康对照组(P<0.05)。血清中VAP-1、VCAM-1水平在甲状腺腺瘤组和健康对照组间差异无统计学意义(P>0.05)。与术前相比,甲状腺癌组术后血清VAP-1水平显著升高(P<0.05),而血清VCAM-1水平显著降低(P<0.05)。术前血清VAP-1、VCAM-1水平在不同肿瘤最大径、肿瘤病理类型、TNM分期、肿瘤分化程度和有无淋巴结转移的甲状腺癌患者中差异有统计学意义(P<0.05),而不同年龄、性别的甲状腺癌患者中术前血清VAP-1、VCAM-1水平差异无统计学意义(P>0.05)。ROC曲线分析结果显示,血清VAP-1和VCAM-1联合检测诊断甲状腺癌的AUC为0.904(95%CI:0.854~0.954),灵敏度为98.25%,特异度为53.25%。结论血清VAP-1和VCAM-1与甲状腺癌患者临床特征密切相关,二者联合检测对甲状腺癌有较高的诊断效能,同时可以用于评估甲状腺癌患者疾病进展,指导临床。Objective To investigate the changes and clinical significance of vascular adhesion protein-1(VAP-1)and vascular cellular adhesion moleculs-1(VCAM-1)in the patients with thyroid cancer.Methods Fift y-seven patients with thyroid cancer admitted to this hospital from July 2020 to May 2022 were selected as the thyroid cancer group,47 patients with thyroid adenoma diagnosed during the same period were selected as the thyroid adenoma group,and 30 healthy subjects undergoing the physical examination in the same period were selected as the healthy control group.ELISA was used to detect serum VAP-1 and VCAM-1 levels in all groups.The differences of serum VAP-1 and VCAM-1 levels among thyroid cancer patients with different clinicopathological parameters were analyzed,and the receiver operating characteristic(ROC)curves were drawn to analyze the diagnostic efficiency of serum VAP-1 and VCAM-1 in diagnosing thyroid cancer.Results The serum VAP-1 level in the thyroid cancer group was significantly lower than that in the thyroid adenoma group and the healthy control group(P<0.05),while the serum VCAM-1 level was significantly higher than that in the thyroid adenoma group and healthy control group(P<0.05).The serum VAP-1 and VCAM-1 levels had no statistically significant difference between the thyroid adenoma group and the healthy control group(P>0.05).Compared with the preoperative level,the serum VAP-1 level after operation in the thyroid cancer group was significantly increased(P<0.05),while the serum VCAM-1 level was significantly decreased(P<0.05).Preoperative serum VAP-1 and VCAM-1 levels had statistically significant difference among thyroid cancer patients with different maximum tumor diameter,tumor pathological types,TNM stages,lymph node metastasis and tumor differentiation(P<0.05).There was no statistically significant difference in preoperative serum VAP-1 and VCAM-1 levels among thyroid cancer patients with different ages and genders(P>0.05).The ROC curve analysis showed that the area under the curve(AUC)of serum

关 键 词：甲状腺癌 血管黏附蛋白-1 血管细胞黏附分子-1 诊断 

分 类 号：R446.1[医药卫生—诊断学]