中医药治疗胰腺纤维化的临床对策及研究进展  

Application of traditional Chinese medicine in treatment of pancreatic fibrosis:Clinical strategies and research advances

作　　者：纪晓丹 龚彪 李兴佳 吕婵[1] 徐莹 JI Xiaodan;GONG Biao;LI Xingjia;LYU Chan;XU Ying(Department of Gastroenterology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Teaching and Experiment Center of Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院消化科,上海201203 [2]上海中医药大学教学实验中心,上海201203

出　　处：《临床肝胆病杂志》2023年第9期2258-2264,共7页Journal of Clinical Hepatology

基　　金：国家自然基金青年科学基金项目(82004162);上海市青年科技英才扬帆计划(20yf1449500);上海中医药大学附属曙光医院“四明青年基金”(SGKJ-201924)。

摘　　要：胰腺纤维化是慢性胰腺炎疾病发展不可逆的主要病理变化,目前临床针对胰腺纤维化的治疗仍缺乏疗效确切的药物。本文总结了近年关于中医药治疗胰腺纤维化的临床策略及研究进展。中医辨证胰腺纤维化涉及到的脏腑有肝、胆、脾、胃;病理因素与火、瘀血、痰湿相关;中药提取物抗胰腺纤维化的相关研究涉及的药物类别包括健脾类、化湿类及化瘀类等,中药方剂治疗胰腺纤维化的相关机制信号通路主要是干预胰腺星状细胞的激活。以上研究为中医药对胰腺纤维化的预防、干预及防治并发症的深入探索提供了参考。Pancreatic fibrosis is the main irreversible pathological change during the progression of chronic pancreatitis,and at present,there is still a lack of effective drugs for the treatment of pancreatic fibrosis in clinical practice.This article summarizes the application of traditional Chinese medicine(TCM)in the treatment of pancreatic fibrosis in recent years from the aspects of clinical strategies and research advances.The TCM syndrome differentiation of pancreatic fibrosis involves the liver,gallbladder,spleen,and stomach,and pathological factors are associated with fire,blood stasis,and phlegm dampness.The research on the anti-pancreatic fibrosis effect of TCM extracts mainly involves spleen-strengthening,dampness-resolving,and blood stasis-resolving drugs,and intervention against the activation of pancreatic stellate cells is the main signaling pathway involved in the mechanism of TCM prescriptions in the treatment of pancreatic fibrosis.The above studies provide a reference for in-depth research on the application of TCM in the prevention and intervention of pancreatic fibrosis and the prevention and treatment of related complications.

关 键 词：胰腺炎 慢性 纤维化 中医药疗法 

分 类 号：R259[医药卫生—中西医结合]