早发性卵巢功能不全的免疫因素分析  

Analysis of immune factors in premature ovarian insufficiency

作　　者：梁伟莹 杨燕宁 谢梅青[1] LIANG Wei-ying;YANG Yanning;XIE Mei-qing(Department of Obstetrics and Gynecology,Sun Yat-sen Memorial Hospital,Sun Yat-sen University,Guangzhou 510120,China)

机构地区：[1]中山大学孙逸仙纪念医院妇产科,广东广州510120

出　　处：《中国实用妇科与产科杂志》2023年第9期878-881,共4页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：国家自然科学基金面上项目(82171670)。

摘　　要：早发性卵巢功能不全(premature ovarian insufficiency,POI)大多发病原因仍未确定,约4%~30%的POI与自身免疫因素相关。自身免疫相关性POI可作为自身免疫性多内分泌腺病综合征(APS)的一部分出现。POI可单独发生,但有时也与其他自身免疫性疾病有关,如原发性慢性肾上腺皮质功能减退症(阿狄森病)、自身免疫性甲状腺疾病(AITD)等。卵巢是自身免疫反应的常见靶点,抗卵巢抗体(AOA)、类固醇细胞抗体(SCA)的存在是自身免疫性POI的主要特征。免疫细胞的紊乱、促炎细胞因子和抗炎细胞因子之间的不平衡在POI的免疫发病机制中也起着重要作用。Most causes of premature ovarian insufficiency(POI)remain undetermined,with 4%-30% of cases originating from autoimmunity.Autoimmuneassociated POI can be a part of autoimmune polyendocrine gland syndrome(APS).POI can also occur independently,while sometimes is associated with other autoimmune diseases,such as primary chronicadrenal insufficiency(Addison's disease),autoimmune thyroid disease(AITD),and others.Ovary is a common target of autoimmune attack,and the presence of antiovarian antibodies(AOA)and steroid cell antibodies(SCA)is a major feature of autoimmune-associated POI.The disturbance of immune cells and the imbalance between pro-inflammatory and anti-inflammatory cytokines also play important roles in the immunopathogenesis of POI.

关 键 词：早发性卵巢功能不全 自身免疫性疾病 抗卵巢抗体 类固醇细胞抗体 免疫细胞 细胞因子 

分 类 号：R711.75[医药卫生—妇产科学]