鼠后肢缺血模型研究进展  

Development of a mouse model for hind limb ischemia

作　　者：张永康 殷康力 宗媛 刘家睿 王御震 曹烨民 ZHANG Yongkang;YIN Kangli;ZONG Yuan;LIU Jiarui;WANG Yuzhen;CAO Yemin(Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Vascular Disease Department of Shanghai Traditional Chinese Medicine Integrated Hospital,Shanghai University ofTraditional Chinese Medicine,Shanghai 200082)

机构地区：[1]上海中医药大学,上海201203 [2]上海中医药大学附属上海市中西医结合医院脉管病科,上海200082

出　　处：《中国实验动物学报》2023年第7期913-921,共9页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家自然科学基金(82174382);重大新药创制科技重大专项(2019ZX09201004-002-091);上海市科委科技创新行动计划(20Z21900200);上海市卫健委临床研究专项(20224Y0387)。

摘　　要：鼠后肢缺血模型是用于研究外周动脉疾病的经典模型。迄今已有鼠动脉结扎法、介入栓塞法、光化学栓塞法、化学损伤、物理损伤和Ameroid收缩器法这六大类造模方法。本文梳理了鼠后肢动脉解剖,对后肢各个主要分支名称进行统一。介绍了鼠后肢缺血模型的造模和模型评价方法,并比较现有方法的差异和优缺点,指出鼠的品系、性别、年龄和麻醉方式对模型的可能影响。总之,本文旨在为读者提供较全面的鼠后肢缺血模型的造模方法,为研究者根据研究方向选择模型提供参考。The mouse hind limb ischemic model is a classic model used to study peripheral arterial disease.Six modeling method have been used to date:arterial ligation,interventional embolization,photochemical embolization,chemical injury,physical injury,and ameroid constrictor.This article reviews the anatomy of the murine hind limb artery and unifies the names of the major branches of the hind limb.We also introduce the modeling and evaluation method used in the mouse hind limb ischemia model,and compare the differences,advantages,and disadvantages of the existing method.Notably,mouse strain,sex,age,and method of anesthesia may affect the model.This report thus provides a comprehensive review of the modeling method of the mouse hind limb ischemia model and provides a reference for researchers to help them to select appropriate models according to their research direction.

关 键 词：后肢缺血 外周动脉疾病 动物模型 鼠类 血栓 血管 

分 类 号：Q95-33[生物学—动物学]