骨质疏松动物模型构建进展与应用特点分析  被引量:9

Establishment and application of osteoporosis animal models

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作  者:李彦冉 闫盼盼 苗艳艳[1] 苗明三[1] LI Yanran;YAN Panpan;MIAO Yanyan;MIAO Mingsan(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区:[1]河南中医药大学药学院,郑州450046

出  处:《中国实验动物学报》2023年第7期928-934,共7页Acta Laboratorium Animalis Scientia Sinica

基  金:国家自然科学基金(82074038);岐黄学者(国中医药人教函2022-6);河南省重大公益专项(201300310100)。

摘  要:随着人口老龄化的加剧,大量骨钙流失,骨质疏松已成为重要的公共卫生问题。骨质疏松被称作“寂静的疾病”,具有高发病、高致残及高致死的特点,严重影响人们的生存质量。目前骨质疏松症动物模型较多,但缺少相关中医药病证因素,为了更贴近临床研究,可结合临床高吻合的模型。本文通过对骨质疏松模型不同造模方式优缺点及动物种类选择优缺点、成模时间、阳性药选择、检测指标的应用现状进行系统综述,为规范化完善动物模型研究提供参考。With the increasing age of the population,and a large amount of bone calcium loss,osteoporosis has become a major public health problem.Osteoporosis is a“silent disease”,with a high incidence,high disability,and high death rates,which seriously affect quality of life.There are many animal models of osteoporosis,but there is a lack of relevant TCM disease and syndrome factors.Therefore,it can be combined with models that are highly consistent with clinical practice to make it closer to clinical research.In this article,we systematically review the advantages and disadvantages of various method of osteoporosis modeling,the advantages and disadvantages of animal species selection,the time of modeling,the drugs selection,and the application of assessment indicators to provide a reference for the standardization and improvement of animal model research.

关 键 词:骨质疏松 动物模型 应用分析 系统综述 

分 类 号:Q95-33[生物学—动物学]

 

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