两种浓度亚甲蓝注射液对肛周脓肿合并糖尿病术后镇痛的效果观察  

Clinical Efficacy Observation of Methylene Blue in Two Concentrations for Postoperative Analgesia of the Patients with Perianal Abscess Complicated with Diabetes Mellitus

作　　者：李建凯 郝伟秀 贾彭松 LI Jian-kai;HAO Wei-ciu;JIA Peng-song(Dept.of Colo-Recto-Ano Surgery,Anyang City's People's Hospital,Anyang,Henan 455000)

机构地区：[1]安阳市人民医院结直肠肛门外科,河南安阳455000

出　　处：《中国肛肠病杂志》2023年第7期44-46,共3页Chinese Journal of Coloproctology

摘　　要：目的:观察两种浓度亚甲蓝注射液对肛周脓肿合并糖尿病患者术后镇痛的临床效果。方法:选取2020年1月至2023年1月我院肛肠科收治肛周脓肿合并糖尿病患者80例,所有患者均行肛周脓肿切开引流一次性根治术,根据术毕给予不同浓度的亚甲蓝注射液分为对照组38例(亚甲蓝浓度0.08%)和观察组42例(亚甲蓝0.2%),比较2组患者术后疼痛程度、空腹血糖、创面愈合程度及创面情况和不良反应发生情况。结果:手术3 d、9 d后,观察组患者疼痛程度评分均明显低于对照组,差异具有统计学意义(P<0.05);手术3 d、9 d后2组患者的空腹血糖及创面愈合程度百分比均无显著性差异(P>0.05);手术后2组患者创面潮湿瘙痒及创面分泌物情况比较差异无统计学意义(P>0.05),观察组患者术后皮肤有烧灼感比例高于对照组,差异具有统计学意义(P<0.05);手术后发生的头晕、恶心、呕吐不良反应观察组明显多于对照组,差异具有统计学意义(P<0.05)。结论:0.2%浓度的亚甲蓝注射液比0.08%的亚甲蓝注射液有更好的镇痛效果,但前者产生皮肤灼痛感及恶心、呕吐等不良反应的可能性更高。Objective To observe the clinical efficacy of methylene blue in two concentrations for postop-erative analgesia of the patients with perianal abscess(PAA)complicated with diabetes mellitus(DM).Methods Enrolled the 80 patients being eligible to above conditions treated in authors department(2020-01-2023-01)into this research:they all received primary radical procedure of incision&drainage,then,according to injecting methylene blue's concentrations were divided into control group(38 cases,the con-centration was 0.08%)and observation group(42 cases,0.2%of methylene blue injection);then,com-pared both groups'patients pain intensity,fasting plasma glucose(FPG),wound-surface healing degree and status,as well as unward reaction incidence.Results At 3,9(days)after surgery the ratings on pain in-tensity in observation group were significantly lower than that in control group(P<0.05),but in FPG and wound-surface healing degree(%)there was no statistical difference between the two groups(P>O.05);after surgery in observation group the ratio of patients having burning feeling of skin,the number of patients suffering dizziness,nausea,and vomiting,etc unward reactions was higher,more significantly than that in control group(all,P<0.05),but in the status on wound-surface moisture&pruritic and secretion there was no statistical difference between the two groups(P>0.05).Conclusion The methylene blue concentration of 0.2%has better analgesia efficacy than that of 0.008%,but the former's possibility mak-ing patients feeling skin-burning pain,as well as the incidence of nausea and vomiting,etc unward reactions are higher than the latter's one.

关 键 词：肛周脓肿 糖尿病 术后疼痛 亚甲蓝 

分 类 号：R614[医药卫生—麻醉学]