贝复新联合高压氧治疗妇产科腹部切口脂肪液化64例疗效观察  

Effects of basic fibroblast growth factor combined with hyperbaric oxygen on 64 cases of abdominal incision fat liquefaction after gynecological and obstetrical surgery

作　　者：滕绍然 杨绍荣 秦云 Teng Shaoran;Yang Shaorong;Qin yun(Department of Gynecology and Obstetrics,The People’s Hospital of Zhaoyuan City,Zhaoyuan 265400,China;Department of Clinical Laboratory,Chongming Hospital Affiliated to Shanghai University of Medicine&Health Sciences,Shanghai 202150,China)

机构地区：[1]山东省招远市人民医院妇产科,招远265400 [2]上海健康医学院附属崇明医院检验科,上海202150

出　　处：《中华航海医学与高气压医学杂志》2023年第4期508-511,528,共5页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的探讨贝复新(外用碱性成纤维细胞生长因子)联合高压氧(HBO)治疗妇产科腹部切口脂肪液化的临床疗效。方法选取2019年3月至2022年10月招远市人民医院妇产科确诊为腹部手术切口脂肪液化的患者128例作为研究对象,采用随机数字表法分为研究组和对照组,每组64例。对照组患者常规清创后采用贝复新纱条引流,创面涂抹贝复新,同时予以红外线照射治疗。研究组患者在对照组治疗的基础上予以HBO治疗。治疗10 d后观察2组患者的临床疗效;记录2组患者脂肪液化消失时间、新肉芽组织生长时间、切口愈合时间和换药总时间;评价切口愈合等级。采用疼痛数字分级法(NRS)评价治疗后第1、4、7、11天患者的疼痛程度。结果研究组患者的临床治疗总有效率(98.44%)明显高于对照组(85.93%),差异有统计学意义(χ^(2)=4.037,P<0.05)。研究组患者的脂肪液化消失时间、新肉芽组织组织生长时间、切口愈合时间、换药总时间均明显短于对照组(P<0.05)。研究组患者的切口愈合情况明显优于对照组(χ^(2)=4.189,P<0.05)。与对照组比较,研究组患者治疗第4、7、11天的NRS评分明显低于对照组(P<0.05或P<0.01)。结论贝复新联合HBO治疗妇产科腹部切口脂肪液化具有较好的临床疗效,能够明显缓解患者的疼痛程度,缩短切口愈合时间,值得临床推广应用。Objective To discuss the clinical effect of basic fibroblast growth factor combined with hyperbaric oxygen(HBO)on the patients with abdominal incision fat liquefaction after gynecological and obstetrical surgery.Methods A total of 128 patients diagnosed as fat liquefaction in abdominal surgical incision in the Department of Gynecology and Obstetrics of The People’s Hospital of Zhaoyuan City from March 2019 to October 2022 were selected as the study subjects and divided into study group and control group by random number table method,with 64 cases in each group.After conventional debridement,the patients in the control group were treated with basic fibroblast growth factor solution gauze for drainage,and the wound surface area was sprayed with basic fibroblast growth factor solution,while infrared radiation was also used.The patients in the study group were treated with hyperbaric oxygen on the basis of the treatment in the control group.After 10 days of treatment,the clinical efficacy of the two groups was observed,the time of fat liquefaction disappearance,the time of new granulation tissue growth,the time of wound healing,and the total time of dressing change were recorded,and the grade of wound healing was evaluated.The degrees of pain on the 1st,4th,7th,and 11th day after the treatment of fat liquefaction in the incision were evaluated,respectively,by the numerical rating scale(NRS).Results After treatment,the total effective rate of the study group(98.44%)was significantly higher than that of the control group(85.93%),with a statistically significant difference(χ^(2)=4.037,P<0.05).The time of fat liquefaction disappearance,the time of new granulation tissue growth,the time of wound healing,and the total time of dressing change in the study group were significantly shorter than those in the control group after treatment(P<0.05).After treatment,the wound healing in the study group was significantly better than that in the control group,with a statistically significant difference(χ^(2)=4.189,P<0.05).Compare

关 键 词：碱性成纤维细胞生长因子 高压氧 妇产科 腹部切口 脂肪液化 

分 类 号：R71[医药卫生—妇产科学]