铁死亡在产科疾病中的研究进展  

Research Progress of Ferroptosis in Obstetric Diseases

作　　者：何玥 崔红梅(审校)[2] HE Yue;CUI Hong-mei(School of Public Health,Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Maternity and Child-Care Hospital/Gansu Provincial Central Hospital,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学公共卫生学院,兰州730000 [2]甘肃省妇幼保健院/甘肃省中心医院

出　　处：《国际生殖健康／计划生育杂志》2023年第5期414-418,共5页Journal of International Reproductive Health/Family Planning

基　　金：甘肃省自然科学基金(22JR5RA725)。

摘　　要：铁死亡是一种新型的程序性细胞死亡方式,主要病理特征是游离铁和脂质过氧化产物的蓄积,主要涉及铁代谢、氨基酸代谢及脂质代谢等过程。近年研究显示,铁死亡通过影响细胞脂质代谢、氧化应激等多种途径导致滋养细胞损伤及胎盘功能障碍,在子痫前期、妊娠期糖尿病、自发性早产、流产及胎儿生长受限等产科疾病的发生、发展中起到重要调控作用。综述铁死亡的发生机制及其与产科疾病的相关性,为深入研究产科疾病的发病机制和治疗方法提供新思路。Ferroptosis is a new type of programmed cell death.The main pathological feature of ferroptosis is the accumulation of free iron and lipid peroxidation products,which mainly involves iron metabolism,amino acid metabolism and lipid metabolism.Recent studies have shown that ferroptosis leads to trophoblastic injury and placental dysfunction through various ways such as affecting cellular lipid metabolism and oxidative stress,and that ferroptosis plays an important regulatory role in the occurrence and development of obstetric diseases such as pre-eclampsia,gestational diabetes mellitus,spontaneous preterm birth,abortion and fetal growth restriction.In this paper,we reviewed the mechanism of ferroptosis and its correlation with obstetric diseases,so as to provide new ideas for further study of the pathogenesis and treatment of obstetric diseases.

关 键 词：铁死亡 铁代谢障碍 氧化性应激 先兆子痫 糖尿病 妊娠 流产 自然 早产 胎儿生长迟缓 

分 类 号：R714[医药卫生—妇产科学]