细孔钻颅微创血肿清除术对高血压脑出血患者血-脑屏障指数、MBP水平的影响  

The Effect of Minimally Invasive Hematoma Removal with Fine Hole Drilling on Blood Brain Barrier Index and MBP Level in Patients with Hypertensive Cerebral Hemorrhage

作　　者：孙伟[1] 岳喜龙[1] 吴玉勤[1] 朱林[1] 任栎冰 沈威 Sun Wei;Yue Xi-long;Wu Yu-qin;Zhu Lin;Ren Li-bing;Shen Wei(Suining County People's Hospital,Suining 221200,China)

机构地区：[1]睢宁县人民医院,睢宁221200

出　　处：《罕少疾病杂志》2023年第9期23-25,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的 分析细孔钻颅微创血肿清除术对高血压脑出血(HICH)患者血-脑屏障(BBB)指数、髓鞘碱性蛋白(MBP)水平的影响。方法 回顾性分析2021年3月-2022年6月期间72例在我院收治的HICH患者病例资料,根据手术方式的不同分成传统组(n=35,行传统开颅血肿清除术)和微创组(n=37,行细孔钻颅微创血肿清除术),对比两组临床疗效、围手术期的指标、BBB指数及MBP水平,对比两组手术后并发症的情况。结果 微创组HICH患者总有效率为91.89%,明显高于传统组的74.29%(P<0.05);微创组HICH患者手术时间、术中出血量以及术后住院时间均优于传统组(P<0.05);术后1周,微创组和传统组术后BBB指数及MBP水平均较手术前下降(P<0.05),且相比传统组,微创组下降的效果更为明显(P<0.05);术后3个月,微创组HICH患者GOS评分高于传统组,微创组NIHSS评分较术前明显下降,且低于传统组(P<0.05);微创组HICH患者手术后感染、继发血肿的发生率显著低于传统组(P<0.05),两组对比血肿清除率以及发生其他并发症的情况差异不明显(P>0.05)。结论 细孔钻颅微创血肿清除术可有效降低BBB指数及MBP水平,提高HICH治疗的效果。Objective To analyze the effect of micro-invasive hematoma removal with fine-hole cranial drilling on blood-brain barrier(BBB)index and myelin basic protein(MBP)level in patients with hypertensive intracerebral hemorrhage(HICH).Methods The clinical data of 72 patients with HICH admitted to our hospital from March 2021 to June 2022 were retrospectively analyzed.According to the different surgical methods,they were divided into the traditional group(n=35,traditional craniotomy hematoma removal)and the minimally invasive group(n=37,fine hole craniotomy minimally invasive hematoma removal).The clinical efficacy,perioperative indicators,BBB index and MBP level were compared between the two groups,and the postoperative complications were compared between the two groups.Results The total effective rate of HICH patients in minimally invasive group was 91.89%,which was significantly higher than that in traditional group(74.29%,P<0.05).The operation time,intraoperative blood loss and postoperative hospital stay of HICH patients in minimally invasive group were better than those in traditional group(P<0.05).At 1 week after operation,BBB index and MBP level in minimally invasive group and traditional group were decreased compared with those before operation(P<0.05),and the effect of minimally invasive group was more obvious than that of traditional group(P<0.05).At 3 months after operation,GOS score of HICH patients in minimally invasive group was higher than that in traditional group,and NI HSS score of minimally invasive group was significantly lower than that before operation,and lower than that of traditional group(P<0.05).The incidence of postoperative infection and secondary hematoma in the minimally invasive group was significantly lower than that in the traditional group(all P<0.05),and there was no significant difference in hematoma clearance rate and other complications between the two groups(all P>0.05).Conclusion Minimally invasive hematoma removal with microhole drilling can effectively reduce the BBB index and

关 键 词：细孔钻颅微创血肿清除术 高血压脑出血 血-脑屏障指数 髓鞘碱性蛋白 

分 类 号：R544.1[医药卫生—心血管疾病] R743.34[医药卫生—内科学]