细胞凋亡在缺血性脑卒中过程中作用的可视化分析  

Visual analysis of the effect of apoptosis on ischemic stroke

作　　者：段彦哲 滑键林 丁智斌 江楠 宋丽娟 闫玉清[1,5] 马存根 Duan Yanzhe;Hua Jianlin;Ding Zhibin;Jiang Nan;Song Lijuan;Yan Yuqing;Ma Cungen(Key Laboratory of Invigorating Qi and Activating Blood Circulation of Multiple Sclerosis/Neurobiology Research Center,State Administration of Traditional Chinese Medicine,Shanxi University of Chinese Medicine,Jinzhong 030619,Shanxi Province,China;Department of Neurosurgery,Sinopharm Coal Group General Hospital,Datong 037003,Shanxi Province,China;Shanxi Bethune Hospital(Tongji Shanxi Hospital,Shanxi Academy of Medical Sciences),The Third Hospital of Shanxi Medical University,Taiyuan 030032,Shanxi Province,China;Key Laboratory of Cell Physiology,Ministry of Education,Shanxi Medical University,Taiyuan 030001,Shanxi Province,China;Department of Neurology,Institute of Brain Science,The First Affiliated Hospital of Shanxi Datong University,Datong 037009,Shanxi Province,China)

机构地区：[1]山西中医药大学国家中医药管理局多发性硬化益气活血重点研究室/神经生物学研究中心,山西省晋中市030619 [2]国药同煤集团总医院神经外科,山西省大同市037003 [3]山西白求恩医院(山西医学科学院同济山西医院),山西医科大学第三医院,山西省太原市030032 [4]山西医科大学细胞生理学省部共建教育部重点实验室,山西省太原市030001 [5]山西大同大学脑科学研究所/附属第一医院神经科,山西省大同市037009

出　　处：《中国组织工程研究》2024年第26期4145-4150,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(82004028),项目负责人:宋丽娟;国家自然科学基金项目(81473577),项目负责人:马存根;中国博士后科学基金面上资助项目(2020M680912),项目负责人:宋丽娟;国家中医药管理局“张仲景传承与创新专项”(GZY-KJS-2022-048-1),项目负责人:宋丽娟;山西省科技创新人才青年团队项目(202204051001028),项目负责人:宋丽娟;山西中医药大学2022年度科技创新团队项目(2022TD2010),项目负责人:宋丽娟、马存根;山西省卫健委医学科技领军团队项目(2020TD05),项目负责人:马存根;山西中医药大学附属医院国家区域中医医疗中心心血管专项基金项目(XGZX202115),项目负责人:宋丽娟;山西中医药大学青年科学家培育项目(2021PY-QN-09),项目负责人:宋丽娟;山西中医药大学学科建设经费(2023XKJS-02),项目负责人:马存根。

摘　　要：背景:缺血性脑卒中是一种与细胞凋亡相关的高发性疾病。在脑缺血后会出现神经元的死亡,包括坏死和凋亡两种方式。缺血核心区以坏死为主,而半暗带内的迟发性神经元死亡则以凋亡为主,半暗带已经成为现在缺血性脑卒中治疗的靶点。此文献计量分析用于确定过去5年缺血性脑卒中中细胞凋亡的全球科学产出特征、热点和前沿。目的:采用文献计量学的方法分析缺血性脑卒中病理过程中细胞凋亡的作用及其机制。方法:从Web of Science Core Collection的科学引文索引扩展(SCI-Expanded)和社会科学引文索引扩展(SSCI-Expanded)中检索2018-2022年缺血性脑卒中中细胞凋亡的相关文献记录927篇。使用citespace、VOSviewer和Bibliometrix对缺血性脑卒中中细胞凋亡的研究趋势和热点进行可视化分析。结果与结论:①在过去5年中,2018-2020年有关细胞凋亡在缺血性脑卒中中的作用发文量呈上升趋势,但在2020年发生转折,发文数量开始下降;其中中国的发文量最多,美国居于第2名;首都医科大学和《BRAIN RESEARCH BULLETIN》分别是发文最多的机构和期刊;近年来,“Expression”和“Oxidative stress”这2个关键词出现的频率较高;②文献计量学研究表明,在过去的5年中,大多数研究主要集中在基础研究上,其中细胞凋亡在缺血性脑卒中中的作用在近3年的研究中逐渐减少,呈现下降趋势;反之,神经再生逐渐成为了一个研究的热点,尤其在不同机制影响下对神经营养因子的调控,以及在血管生成和胶质细胞修复方面的研究呈上升趋势,同时在神经再生中细胞凋亡是一个潜在的发掘点。BACKGROUND:Ischemic stroke is a highly prevalent disease associated with apoptosis.Neuronal death occurs after cerebral ischemia,including necrosis and apoptosis.The ischemic core region is dominated by necrosis,while delayed neuronal death in the penumbra is dominated by apoptosis.The penumbra has become a target for the treatment of ischemic stroke.This bibliometric analysis was used to identify the characteristics,hotspots,and frontiers of global scientific output related to apoptosis in ischemic stroke over the past 5 years.OBJECTIVE:To analyze the role of apoptosis and its mechanisms in the pathological process of ischemic stroke through a bibliometric approach.METHODS:A total of 927 relevant literature records from 2018 to 2022 were retrieved from Science Citation Index Expanded(SCI-Expanded)and Social Science Citation Index Expanded(SSCI-Expanded)of the Web of Science Core Collection.Research trends and hotspots of apoptosis in ischemic stroke were visualized using Citespace,VOSviewer and Bibliometrix.RESULTS AND CONCLUSION:From 2018 to 2020,the number of papers on the role of apoptosis in ischemic stroke showed an upward trend,but in 2020,the number of papers began to reduce.China had the largest number of publications,and the United States ranked the second.Capital Medical University and BRAIN RESEARCH BULLETIN were the institutions and journals with the most articles,respectively.In recent years,the two keywords“expression”and“oxidative stress”have appeared more frequently.The bibliometric study showed that in the past 5 years,most of the studies focused on basic research,in which research on the role of apoptosis in ischemic stroke has gradually decreased in the last 3 years,showing a downward trend.On the contrary,nerve regeneration has gradually become a research hotspot,especially the regulation of neurotrophic factors under the influence of different mechanisms,and the research on angiogenesis and glial cell repair is on the rise.At the same time,apoptosis in nerve regeneration is a potenti

关 键 词：文献计量学 细胞凋亡 缺血性脑卒中 VOSviewer CITESPACE 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学] R743.3