直链淀粉三(3,5-二甲基苯基氨基甲酸酯)-聚醚砜手性膜色谱研究  

Chiral Membrane Chromatography Study Based on Amylose-tris-(3,5-dimethylphenylcarbamate)-Polyethersulfone

作　　者：普娜 赖亚琳 高顺秋 蒋雪菲 袁黎明[1] PU Na;LAI Yalin;GAO Shunqiu;JIANG Xuefei;YUAN Liming(Department of Chemistry and Chemical Engineering,Yunnan Normal University,Kunming 650500,China)

机构地区：[1]云南师范大学化学化工学院,云南昆明650500

出　　处：《分析测试技术与仪器》2023年第3期280-285,共6页Analysis and Testing Technology and Instruments

基　　金：国家自然科学基金项目(22174125)。

摘　　要：以直链淀粉三(3,5-二甲基苯基氨基甲酸酯)为材料,利用相转化法制备直链淀粉三(3,5-二甲基苯基氨基甲酸酯)-聚醚砜手性高分子膜.使用自制的手性膜色谱装置与高效液相色谱仪结合,对手性物质盐酸普萘洛尔和美托洛尔进行了手性膜色谱分离研究.研究了进样量、流速、膜尺寸对分离效果的影响.在优选分离效果的条件下,手性膜色谱以纯水为流动相,测得盐酸普萘洛尔的分离因子(α)和分离度(Rs)分别为3.00和0.95,美托洛尔的α和Rs分别为1.65和0.46.为手性化合物的分离分析开拓了新的途径.The chiral membrane of amylose-tris-(3,5-dimethylphenylcarbamate)-polyethersulfone was prepared by phase conversion method using the amylose-tris-(3,5-dimethylphenylcarbamate)as the material.The chiral membrane chromatographic separation of propranolol hydrochloride and metoprolol were studied by using the self-made chiral membrane chromatographic device combined with a high performance liquid chromatograph.The effects of injection volume,flow rate and membrane size on the separation of membrane were studied.Under the optimal conditions,the separation factors(α)and resolution(Rs)with water as mobile phase were 3.00 and 0.95 for propranolol hydrochloride,1.65 and 0.46 for metoprolol,respectively.The study opens up a new way for the isolation and analysis of chiral compounds.

关 键 词：手性膜色谱 手性分离 盐酸普萘洛尔 美托洛尔 

分 类 号：O657.7[理学—分析化学]