乳酸菌阴道胶囊辅助治疗在行ART反复着床失败患者中的应用  

The application of lactobacillus vaginal capsule adjuvant therapy in patients with repeated implantation failure of ART

作　　者：肖彭莹[1] 苑晓微[1] XIAO Pengying;YUAN Xiaowei(Department of Reproductive Health and Infertility,Kunming Maternal and Child Health Hospital,Kunming,Yunnan 650118,China;不详)

机构地区：[1]昆明市妇幼保健院生殖健康与不孕不育科,云南昆明650118

出　　处：《中国微生态学杂志》2023年第7期817-820,825,共5页Chinese Journal of Microecology

基　　金：昆明市卫生健康委员会卫生科研课题项目(2021-05-01-0010);云南省生殖妇产疾病临床医学中心(zx2019-01-01);云南省生殖妇产疾病临床医学中心开放课题(2021LCZXXF-SZ17)。

摘　　要：目的 探究行辅助生殖技术(ART)反复着床失败患者应用乳酸菌阴道胶囊辅助治疗对子宫内膜容受性(ER)和阴道微生物的影响。方法选取2020年5月至2022年5月本院收治ART反复着床失败患者100例,根据治疗方式分为观察组(n=50)和对照组(n=50)。对照组采用常规治疗,观察组采用常规治疗联合乳酸菌阴道胶囊。比较两组的性激素水平(雌二醇、孕酮),内膜容积、子宫内膜厚度、血管血流指数(VFI)、内膜血流指数(FI)和阻力指数(RI)等子宫内膜容受性指标,阴道pH值、阴道菌群检出率和乳酸菌数量。结果 两组治疗前后血清雌二醇、孕酮水平比较,差异无统计学意义(P>0.05)。两组治疗前子宫内膜厚度、内膜容积、血管血流指数、内膜血流指数和阻力指数比较,差异无统计学意义(P>0.05)。治疗后观察组子宫内膜厚度、内膜容积和血管血流指数均高于治疗前(P<0.01)和对照组(P<0.05)。治疗前两组菌群检出率差异无统计学意义(P>0.05),治疗后两组菌群检出率均低于治疗前(P<0.05),治疗后观察组菌群检出率低于对照组(P<0.05)。两组阴道pH值均低于治疗前(P<0.001),治疗后观察组阴道pH值低于对照组(P<0.001)。两组阴道乳杆菌正常率均高于治疗前(P<0.05),治疗后观察组高于对照组(P<0.05)。两组胚胎着床率、临床妊娠率、早期流产率和持续妊娠率差异无统计学意义(P> 0.05)。结论 乳酸菌阴道胶囊治疗ART反复着床失败患者可以改善子宫内膜容受性和阴道菌群。Objective To observe the effects of lactobacillus vaginal capsule on endometrial receptivity(ER)and vaginal microorganisms in patients with repeated implantation failure of assisted reproductive technology(ART).Methods From May 2020 to May 2022,100 patients with repeated implantation failure of ART were selected.According to the treatment methods,they were divided into observation group(n=50)and control group(n=50).The control group was given conventional treatment,and the observation group was given conventional treatment combined with lactobacillus vaginal capsule.The levels of sex hormones(estradiol,progesterone),endometrial receptivity indices including endometrial volume,endometrial thickness,vascularization flow index(VFI),endometrial blood flow index(FI),resistance index(RI),vaginal pH value,flora detection rate,and count of lactic acid bacteria were compared between the two groups.Results There were no statistically significant differences in serum estradiol and progesterone levels between the two groups before and after treatment(P>0.05),nor in endometrial thickness,endometrial volume,vascular flow index,endometrial flow index,and resistance index between the two groups before treatment(P>0.05).After treatment,the endometrial thickness,endometrial volume,and vascular flow index in the observation group were higher than those before treatment(P<0.01)and those in the control group(P<0.05).Before treatment,there was no statistically significant difference in the detection rate of bacteria between the two groups(P>0.05).After treatment,the detection rates of bacterial communities in both groups were lower than before treatment(P<0.05);that in the observation group was lower than that in the control group after treatment(P<0.05).The vaginal pH value in both groups were lower than before treatment(P<0.001),and after treatment,that in the observation group were lower than that in the control group(P<0.001).The normal rates of vaginal lactobacilli in both groups were higher than before treatment(P<0.05);after tr

关 键 词：乳酸菌阴道胶囊 辅助生殖技术 反复着床失败 子宫内膜容受性 阴道菌群 

分 类 号：R714[医药卫生—妇产科学]