益生菌对非酒精性脂肪性肝病的治疗及对肠功能的影响  

Effect of probiotics for treatment of non-alcoholic fatty liver disease and on intestinal function

作　　者：杜君义[1] 梅璐[1] 于泳[1] DU Junyi;MEI Lu;YU Yong(Department of Gastroenterology,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou,He'nan 450014,China;不详)

机构地区：[1]郑州大学第五附属医院消化内科,河南郑州450014

出　　处：《中国微生态学杂志》2023年第7期821-825,共5页Chinese Journal of Microecology

基　　金：河南省科技英才海外研修工程项目(2018125);河南省医学科技攻关项目(2018020237,2018020228)。

摘　　要：目的 探讨双歧杆菌三联活菌对非酒精性脂肪性肝病患者的临床疗效及对小肠细菌过度生长、肠屏障功能的影响。方法 选取180例诊断为非酒精性脂肪性肝病的患者,将其随机分成对照组(90例)和治疗组(90例)。对照组患者在健康宣教、运动指导、饮食控制的基础上给予多烯磷脂酰胆碱治疗,治疗组患者在对照组的基础上加用双歧杆菌三联活菌治疗。在治疗前及治疗后分别检测两组患者的肝功能、空腹血糖、血脂、肠黏膜屏障功能、氢呼气试验等指标,观察变化并评估疗效。结果 治疗前两组患者的肝功能、血脂、空腹血糖、小肠细菌过度生长阳性率、肠屏障功能差异均无统计学意义(均P>0.05)。治疗8周后,两组患者天门冬氨酸氨基转移酶、丙氨酸氨基转移酶、甘油三酯、总胆固醇、低密度脂蛋白、空腹血糖、D-乳酸、二胺氧化酶、血清内毒素水平均降低(均P<0.05);治疗后治疗组患者氢呼气试验阳性率(20.00%)较治疗前(53.33%)显著下降(P<0.05),而对照组无显著改变(P>0.05)。结论 对非酒精性脂肪性肝病的治疗,常规治疗联合双歧杆菌三联活菌可抑制患者小肠细菌过度生长,改善肠黏膜屏障功能,改善患者的肝功能及血脂、血糖代谢情况。Objective To observe the effects of Triple Viable Bifid capsule on small intestinal bacterial overgrowth and intestinal mucosal barrier function of patients with non-alcoholic fatty liver disease(NAFLD),and evaluate its clinical efficacy.Methods A total of 180 cases of NAFLD were collected and randomly divided into therapy group(90 cases)and control group(90 cases).The patients in the control group received polyene phosphatidylcholine and conventional therapy,including health education,exercise guidance and diet therapy for eight weeks,while those in the therapy group received Triple Viable Bifid capsule combined with the treatment given to control group.The liver function,fast blood glucose(FBG),blood lipid level,Lactulose hydrogen breath test,intestinal mucosal barrier function were observed before and after the treatment.Results Before the treatment,there were not significant differences in the liver function(AST,ALT),fast blood glucose,blood lipid levels(TC,TG,LDL,HDL),postive rate of lactulose hydrogen breath test,intestinal mucosal barrier function(ET,DAO,D-Lac)between the two groups(all P>0.05).After the treatment,the levels of ALT,AST,TG,TC,LDH,ET,DAO and D-lac in the two groups were significantly lower than before the treatment(all P<0.05),with the therapy group significantly superior to the control group(all P<0.05);the postive rate of IBSO in the therapy group was lower than before(20.00%vs 53.33%),but in the control group there was no significant change(P>0.05).Conclusion Combination of the conventional therapy with Triple Viable Bifid capsule can effectively repress the small intestinal bacterial overgrowth,improve intestinal mucosal barrier function,liver function,and metabolisms of blood lipid andglucose.

关 键 词：非酒精性脂肪性肝病 双歧杆菌三联活菌 小肠细菌过度生长 肠黏膜屏障功能 临床疗效 

分 类 号：R451[医药卫生—治疗学]