苯丙氨酸在宿主和肠道微生物中的代谢研究进展  

Metabolism of phenylalanine in host and intestinal microorganism:research progress

作　　者：白新书 胡天骄 薛鑫 董秀山[1] BAI Xinshu;HU Tianjiao;XUE Xin;DONG Xiushan(Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences,Tongji Shanxi Hospital,Taiyuan,Shanxi 030032,China;不详)

机构地区：[1]山西医科大学第三医院(山西白求恩医院,山西医学科学院,同济山西医院),山西太原030032

出　　处：《中国微生态学杂志》2023年第7期857-859,863,共4页Chinese Journal of Microecology

基　　金：中国营养学会-振东国人体质与健康研究基金(CNS-ZD2020-59)。

摘　　要：肠道微生物是宿主生理活动的重要参与者,与宿主的健康和疾病密切相关。研究表明,肠道微生物代谢产物是饮食诱导宿主-微生物相互作用的关键介质,这些代谢产物由微生物直接产生或由环境和宿主中相关分子的代谢转化产生。宿主和肠道微生物之间的化学对话是影响宿主生理的重要环节,对这些代谢途径和信号通路的研究可以进一步揭示微生物代谢与宿主的相互作用机制。芳香族氨基酸包括苯丙氨酸、酪氨酸和色氨酸,是宿主-微生物相互作用的重要信号分子,在胃肠道和远隔器官中发挥着重要的调节作用。本文就苯丙氨酸与肠道微生物的最新研究进展进行综述,重点阐述苯丙氨酸在宿主和肠道微生物中的代谢情况。Intestinal microorganisms are important participants in host physiological activities and are closely related to host health and diseases.Studies have shown that intestinal microbial metabolites are the key mediators of diet-induced host-microbe interactions,and these metabolites are produced directly by microorganisms or from the metabolic transformation of related molecules in the environment and host.The chemical dialogue between host and intestinal microorganisms is an important link in host physiology.The study on these metabolic pathways and signaling pathways can further reveal the mechanisms of interactions between microbial metabolism and host.Aromatic amino acids,including phenylalanine,tyrosine and tryptophan,are important signaling molecules in host-microbial interaction and play important regulatory roles in gastrointestinal tract and distant organs.In this paper,we reviewed the latest progress in research on phenylalanine and intestinal microorganisms,focusing on the metabolism of phenylalanine in host and intestinal microorganisms.

关 键 词：芳香族氨基酸 苯丙氨酸 肠道微生物 宿主-微生物相互作用 

分 类 号：R37[医药卫生—病原生物学]