m^(6)A甲基化修饰对畜禽生产影响的研究进展  

Research progress of m^(6)A methylation modification in livestock and poultry

作　　者：张娟丽[1,2,3] 杨姣姣 杨巧丽[3] 黄晓宇 ZHANG Juanli;YANG Jiaojiao;YANG Qiaoli;HUANG Xiaoyu(College of Life Science and Technology,Longdong,University,Qingyang,Gansu 745000,China;Gansu Longdong Key Laboratory of Biological Resources Conservation,Utilization and Ecological Restoration,Qingyang,Gansu 745000,China;College of Animal Science and Technology,Gansu Agricultural University,Lanzhou 730070,China)

机构地区：[1]陇东学院生命科学与技术学院,甘肃庆阳745000 [2]甘肃省陇东生物资源保护利用与生态修复重点实验室,甘肃庆阳745000 [3]甘肃农业大学动物科学技术学院,甘肃兰州730070

出　　处：《中国兽医学报》2023年第6期1333-1341,共9页Chinese Journal of Veterinary Science

基　　金：陇东学院博士科研启动基金资助项目(XYBYZK2210);国家自然科学基金资助项目(31960646)。

摘　　要：m^(6)A甲基化修饰是RNA修饰中最为普遍的一种,主要通过甲基化相关酶的可逆调节而影响RNA的代谢,如RNA运输、可变剪切、翻译及稳定性。通过对m^(6)A甲基化修饰的分布特征、检测方法优缺点、种类及在畜禽生长发育、生殖、脂肪代谢、炎症反应中的调节作用的综述,为m^(6)A甲基化修饰在畜禽各性状中的研究提供新的见解和思路。m^(6)A methylation modification is the most common modification of RNA,which mainly affects RNA metabolism by reversible regulation of methylation related enzymes,such as RNA transport,variable splicing,translation and stability.This paper mainly summarizes the distribution,characteristics,advantages and disadvantages of detection methods,types,and the regulatory role of m^(6)A modification in animal growth and development,reproduction,fat metabolism and animal inflammatory response,providing new insights and ideas for the study of m^(6)A in livestock and poultry.

关 键 词：m^(6)A甲基化修饰 甲基化相关酶 畜禽 生长发育 脂肪代谢 免疫炎症反应 

分 类 号：S852[农业科学—基础兽医学]