扬州市某医院2021年1~79岁人群乙型肝炎病毒标志物血清流行率分析  

Sero-prevalence analysis of Hepatitis B virus markers among the 1-79-year-old population in a hospital in Yangzhou City in 2021

作　　者：金鑫 周文杰 彭睿 王翱卿 王丽萍[1] 姚京京 鲁军[1] JIN Xin;ZHOU Wenjie;PENG Rui;WANG Aoqing;WANG Liping;YAO Jingjing;LU Jun(Northern Jiangsu People's Hospital Affiliated to Yangzhou University,Yangzhou,Jiangsu 225001,China)

机构地区：[1]扬州大学附属苏北人民医院,江苏扬州225001

出　　处：《医学动物防制》2023年第8期722-726,共5页Journal of Medical Pest Control

基　　金：国家自然科学基金项目(82203716);苏北人民医院院级基金项目(SBKY21014)。

摘　　要：目的了解扬州市1~79岁人群乙型肝炎病毒(Hepatitis B virus,HBV)血清标志物流行率并进行具体分析。方法收集2021年1—12月在扬州市某医院开展乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)、乙型肝炎表面抗体(hepatitis B surface antibody,HBsAb)、乙型肝炎e抗原(hepatitis B e antigen,HBeAg)、乙型肝炎e抗体(hepatitis B e antibody,HBeAb)和乙型肝炎核心抗体(hepatitis B core antibody,HBcAb)检测的85797例患者的病历资料和检查结果,分析其血清流行率。结果该医院就诊的1~79岁人群HBsAg、HBsAb、HBcAb阳性率分别为8.36%、48.89%、54.24%。HBsAg阳性率随年龄增长呈上升趋势(χ_(趋势)^(2)=198.048,P<0.01),1~<9岁人群HBsAg阳性率为0.07%,31~<61岁人群HBsAg阳性率为10.44%。男性HBsAg阳性率(10.12%)显著高于女性(6.66%),差异有统计学意义(χ^(2)=335.535,P<0.01)。HBsAg阳性人群中HBeAg和HBeAb阳性检出率分别为9.12%和88.49%。乙肝疫苗(hepatitis B vaccine,HepB)纳入扩大免疫接种规划管理前后,1~<31岁和31~≤79岁人群HBsAg阳性率分别为2.79%和9.36%,差异有统计学意义(χ^(2)=624.324,P<0.01)。育龄期女性HBsAg阳性率为5.68%,HBsAg阳性人群中HBeAg阳性率为16.92%。结论扬州市HBsAg阳性率儿童较低,成人较高,阳性人群以中青年为主,且男性高于女性。提示在巩固儿童常规免疫工作的同时,应加强成人尤其是中青年男性的乙肝防治工作。Objective To learn about the prevalence rate of Hepatitis B virus(HBV)serum markers among people aged 1-79-year-old population in Yangzhou City,and made a concrete analysis of that.Methods Clinical data and examination results of 85797 patients who underwent hepatitis B tests in a hospital in Yangzhou City from January to December 2021 were collected.The tests included hepatitis B surface antigen(HBsAg),hepatitis B surface antibody(HBsAb),hepatitis B e antigen(HBeAg),hepatitis B e antibody(HBeAb),and hepatitis B core antibody(HBcAb).Results The positive rates of HBsAg,HBsAb,and HBcAb among people aged 1-79-year-old population attended in this hospital were 8.36%,48.89%,and 54.24%,respectively.The HBsAg positive rate increased with age(χ^(2)_(trend)=198.048,P<0.01),among which the positive rate of 1-<9-year-old population was 0.07%,and that of 31-<61-year-old population was 10.44%.The HBsAg positive rate of males(10.12%)was extremely higher than that of females(6.66%),and the dfference was statistically significant(χ^(2)=335.535,P<0.01).Among HBsAg-positive people,the positive rates of HBeAg and HBeAb were 9.12%and 88.49%,respectively.Before and after the hepatitis B vaccine(HepB)was introduced into the expanded program immunization(EPI),the HBsAg positive rates of 1-<31-year-old population and 31-≤79-year-old population were 2.79%and 9.36%,respectively,and the differences were statistically significant(χ^(2)=624.324,P<0.01).The HBsAg positive rate was 5.68%in women of childbearing age,and among them,the HBeAg positive rate was 16.92%.Conclusion HBV positive rates in Yangzhou City are low among children but high among adults.The positive rate of males is higher than that of females,positive population mainly consists of middle-aged and young people,with more males than females.We should strengthen the prevention and treatment of hepatitis B among adults,especially middle-aged and young people while consolidating the routine immunization of children.

关 键 词：乙型肝炎病毒 标志物 血清流行率 乙肝疫苗 防治 分析 

分 类 号：R512.62[医药卫生—内科学]