免疫细胞在增生性瘢痕形成中免疫调控机制的研究进展  

The research progress of immunoregulatory mechanism of immune cells in hypertrophic scar formation

作　　者：赵文 崔荣涛 Zhao Wen;Cui Rongtao(Department of Burn and Plastic Surgery,Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)

机构地区：[1]山东第一医科大学附属省立医院烧伤整形外科,济南250021

出　　处：《中华整形外科杂志》2023年第8期907-915,共9页Chinese Journal of Plastic Surgery

基　　金：国家自然科学基金(81901968);山东省自然科学基金(ZR2019BH051);中国博士后科学基金(2018M642667)。

摘　　要：增生性瘢痕(HS)是创伤后局部组织修复异常增生的结果,其易增生、复发,不仅影响美观,还可能导致功能障碍,是临床上的一大难题。该文总结了不同免疫细胞及其免疫分子在创面修复、愈合及瘢痕形成过程中发挥的不同作用机制,对现有的HS的免疫疗法进行了概述,以为学者们进一步研究HS提供参考。Hypertrophic scar(HS)is the result of abnormal hyperplasia of local tissue repair after trauma,which commonly proliferates and relapses.The scars affect the beauty or lead to dysfunction.It has always been a major problem for clinical doctors.This review summarized the mechanisms of different immune cells and their immune molecules in the process of wound healing and scar formation,and sketched the existing hypertrophic scar immunotherapies to provide references for researchers to further study HS.

关 键 词：瘢痕 增生性瘢痕 免疫细胞 免疫分子 自然杀伤细胞 免疫疗法 

分 类 号：R622[医药卫生—整形外科]